LM-UNet: Lightweight Mamba-UNet Prostate MRI image segmentation network

K Kuncai Xu S Shuai Zhou (Department of Global Development, Cornell University) Y Yan Chen J Junhao Chen N Ning Zhang Y Yilong Liao

Abstract

Accurate segmentation of lesions in prostate magnetic resonance images (MRI) is important for assessing patient health and personalized treatment in the clinic. However, the traditional UNet segmentation network has low segmentation accuracy because of the fuzzy boundary and low contrast. Therefore, we propose a Lightweight Mamba-UNet (LM-UNet) prostate MRI image segmentation method. Initially, the encoder-decoder backbone structure consists of parallel vision mamba (PV-Mamba) and efficient multi-scale attention (EMA). The number of model parameters is reduced by constructing PV-Mamba while extracting the correlation between features over long distances. The EMA is then used to learn different spatial features in groups and construct cross-spatial information aggregation methods for richer feature aggregation. Subsequently, we construct the edge feature extraction (EFE) and the edge feature fusion (EFF) to achieve different levels of feature fusion in the encoder. Ultimately, we suggest a multi-stage and multi-level skip connections (MMSC) to achieve multi-level fusion between the encoder and decoder, there reducing semantic discrepancies between contextual features and improving segmentation accuracy. Experimental results demonstrate that on the PROMISE12 dataset, LM-UNet outperforms seven comparative segmentation methods in terms of parameter count, computational memory requirements, and precise segmentation of lesion margins.

Article Details

Journal PLoS ONE
Volume / Issue Vol. 21, Issue 3
Published March 23, 2026
Pages e0339719
ISSN 1932-6203
Publisher Public Library of Science

Journal Info

PLoS ONE

Public Library of Science

ISSN: 1932-6203 Open Access Health Sciences

Authors (6)

K

Kuncai Xu

S

Shuai Zhou

Department of Global Development, Cornell University

Y

Yan Chen

J

Junhao Chen

N

Ning Zhang

Y

Yilong Liao