Lightweight and interpretable edge intelligence AI with intrusion detection for trustworthy cardiac arrhythmia in medical IoT

M Muhammad Imran Khalid A Altaf Hussain N Nasir Hussain T Tamim Alkhalifah

Abstract

Abstract Medical Internet of Things (MIoT) systems enable continuous cardiac monitoring, but practical deployment is limited by three issues: heavy computation at the edge, limited interpretability, and vulnerability to cyber-attacks that can corrupt signals and degrade inference. We propose CLARITY-AI 2.0, a lightweight and trustworthy arrhythmia detection framework for MIoT that combines efficient ECG feature extraction, interpretable prediction, and security-aware trust assessment. The model performs arrhythmia inference using a compact feature-based learner and generates clinician-facing explanations via SHAP attributions, which are converted into structured natural-language reports using an LLM. To improve trust under hostile network conditions, an intrusion detection module outputs an attack probability and a trust score that flags unreliable inputs. On the MIT-BIH benchmark, CLARITY-AI 2.0 achieves an F1 score of 0.928 and an AUC of 0.985 for anomaly detection. It also generalizes under dataset shift with an AUC of 0.940 on PTB-XL and an AUC of 0.915 on Chapman (zero-shot evaluation). For edge feasibility, deployment on an ESP32 reduces the footprint to 350 KB, peak RAM to 120 KB, and inference latency to 8.1 ms, supporting real-time operation on resource-constrained devices. These results indicate that CLARITY-AI 2.0 is an interpretable, efficient, and security-aware approach toward scalable MIoT-based cardiac monitoring.

Article Details

Volume / Issue Vol. 16, Issue 1
Published March 24, 2026
ISSN 2045-2322
Publisher Nature Portfolio

Journal Info

Scientific Reports

Nature Portfolio

ISSN: 2045-2322 Open Access Life Sciences

Authors (4)

M

Muhammad Imran Khalid

A

Altaf Hussain

N

Nasir Hussain

T

Tamim Alkhalifah