Light-Activated Metal-Dependent Protein Degradation: A Heterobifunctional Ruthenium(II) Photosensitizer Targeting New Delhi Metallo-β-lactamase 1

L Lars Stevens-Cullinane (Department of Chemistry) T Thomas W. Rees (The Biological Inorganic Chemistry Laboratory) C Calum Evans (Department of Chemistry) P Po-Yu Ho (Department of Chemistry) M Mika Kintzel (Department of Chemistry) Y Yew Mun Yip (Chemical Biology Science and Technology Platform) R Ruoning Jia (Department of Chemistry) J Jonathan Bailey (The Biological Inorganic Chemistry Laboratory) E Eleanor Clifford (Department of Chemistry) R Ruqaiya Alam (Department of Chemistry) S Sarah Maslen S Stephane Mouilleron (Structural Biology Science and Technology Platform) A Adrien Pasquier (High Throughput Screening Science and Technology Platform) O Ok-Ryul Song (High Throughput Screening Science and Technology Platform) S Scott Warchal (High Throughput Screening Science and Technology Platform) J Joanna Redmond (Chemical Biology Science and Technology Platform) M Michael Howell (High Throughput Screening Science and Technology Platform) S Svend Kjær (Structural Biology Science and Technology Platform) M Mark Skehel M Manuel M. Müller (Department of Chemistry) E Eachan O. Johnson (Systems Chemical Biology of Infection and Resistance Laboratory) M Maxie M. Roessler (Department of Chemistry and Centre for Pulse EPR Spectroscopy, Imperial College London, Molecular Sciences Research Hub, 82 Wood Lane, London W12 0BZ, U.K.) J Jeannine Hess (Department of Chemistry)

Article Details

Volume / Issue Vol. 147, Issue 49
Published December 10, 2025
Pages 44860-44874
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (23)

L

Lars Stevens-Cullinane

Department of Chemistry

T

Thomas W. Rees

The Biological Inorganic Chemistry Laboratory

C

Calum Evans

Department of Chemistry

P

Po-Yu Ho

Department of Chemistry

M

Mika Kintzel

Department of Chemistry

Y

Yew Mun Yip

Chemical Biology Science and Technology Platform

R

Ruoning Jia

Department of Chemistry

J

Jonathan Bailey

The Biological Inorganic Chemistry Laboratory

E

Eleanor Clifford

Department of Chemistry

R

Ruqaiya Alam

Department of Chemistry

S

Sarah Maslen

S

Stephane Mouilleron

Structural Biology Science and Technology Platform

A

Adrien Pasquier

High Throughput Screening Science and Technology Platform

O

Ok-Ryul Song

High Throughput Screening Science and Technology Platform

S

Scott Warchal

High Throughput Screening Science and Technology Platform

J

Joanna Redmond

Chemical Biology Science and Technology Platform

M

Michael Howell

High Throughput Screening Science and Technology Platform

S

Svend Kjær

Structural Biology Science and Technology Platform

M

Mark Skehel

M

Manuel M. Müller

Department of Chemistry

E

Eachan O. Johnson

Systems Chemical Biology of Infection and Resistance Laboratory

M

Maxie M. Roessler

Department of Chemistry and Centre for Pulse EPR Spectroscopy, Imperial College London, Molecular Sciences Research Hub, 82 Wood Lane, London W12 0BZ, U.K.

J

Jeannine Hess

Department of Chemistry