Ligand-Relay Strategy Enabling Copper-Catalyzed C–C/C–O/C–N Cascade Trifunctionalization of Internal Alkynes and Propargylic Sites: Synthesis of Benzofuran-β-Lactams

L Le Wang J Jie Xiao Z Zi-Hao Li (University of British Columbia, Department of Chemistry, 2036 Main Mall, Vancouver, British Columbia V6T 1Z1, Canada) S Shen-Yuan Zhang (State Key Laboratory of Synergistic Chem-Bio Synthesis, Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering) Y Yuan She (State Key Laboratory of Synergistic Chem-Bio Synthesis, Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering) S Shu-Yu Zhang (State Key Laboratory of Synergistic Chem-Bio Synthesis, Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering)

Article Details

Volume / Issue Vol. 148, Issue 1
Published January 14, 2026
Pages 1683-1691
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (6)

L

Le Wang

J

Jie Xiao

Z

Zi-Hao Li

University of British Columbia, Department of Chemistry, 2036 Main Mall, Vancouver, British Columbia V6T 1Z1, Canada

S

Shen-Yuan Zhang

State Key Laboratory of Synergistic Chem-Bio Synthesis, Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering

Y

Yuan She

State Key Laboratory of Synergistic Chem-Bio Synthesis, Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering

S

Shu-Yu Zhang

State Key Laboratory of Synergistic Chem-Bio Synthesis, Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering