Ligand non-competitive GITR antibody prevents formation of the obligatory signal-triggering GITRL: GITR stoichiometry

Jing Yan; Jessica Min-DeBartolo; Ching-Shin Huang; M. Nusrat Sharif; Li Li; Susan Fish; Corey Dower; Denise Murphy; Tatyana Andreyeva; Heng Liu; Xinbing Han; Wei Zheng; Jot Hui Ooi; Jason Edmonds; Ting Chen; Zachary Maben; Chad R. Stevens; Polina Goihberg; Malgorzata Nocula-Lugowska; Steven M Evans; Lidia Mosyak; Kerry Kelleher; Caitlyn Dickinson; Martin Hegen; Aaron Winkler; Fridrik Karlsson

doi:10.1038/s41598-025-32541-6

Ligand non-competitive GITR antibody prevents formation of the obligatory signal-triggering GITRL: GITR stoichiometry

J Jing Yan J Jessica Min-DeBartolo C Ching-Shin Huang M M. Nusrat Sharif L Li Li S Susan Fish C Corey Dower D Denise Murphy T Tatyana Andreyeva H Heng Liu X Xinbing Han W Wei Zheng J Jot Hui Ooi J Jason Edmonds T Ting Chen Z Zachary Maben C Chad R. Stevens P Polina Goihberg M Malgorzata Nocula-Lugowska S Steven M Evans L Lidia Mosyak K Kerry Kelleher C Caitlyn Dickinson M Martin Hegen A Aaron Winkler F Fridrik Karlsson

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Article Details

Journal Scientific Reports

Volume / Issue Vol. 16, Issue 1

Published December 18, 2025

DOI 10.1038/s41598-025-32541-6

ISSN 2045-2322

Publisher Nature Portfolio

Journal Info

Scientific Reports

Nature Portfolio

ISSN: 2045-2322 Open Access Life Sciences

Authors (26)

J

Jing Yan

J

Jessica Min-DeBartolo

C

Ching-Shin Huang

M

M. Nusrat Sharif

L

Li Li

S

Susan Fish

C

Corey Dower

D

Denise Murphy

T

Tatyana Andreyeva

H

Heng Liu

X

Xinbing Han

W

Wei Zheng

J

Jot Hui Ooi

J

Jason Edmonds

T

Ting Chen

Z

Zachary Maben

C

Chad R. Stevens

P

Polina Goihberg

M

Malgorzata Nocula-Lugowska

S

Steven M Evans

L

Lidia Mosyak

K

Kerry Kelleher

C

Caitlyn Dickinson

M

Martin Hegen

A

Aaron Winkler

F

Fridrik Karlsson

Ligand non-competitive GITR antibody prevents formation of the obligatory signal-triggering GITRL: GITR stoichiometry

Article Details

Journal Info

Authors (26)

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