Ligand-Induced Self-Complementing Tag (LiSC-Tag) as an Epitope Tag for Live-Cell Super-Resolution Imaging and Functional Manipulation of Cellular Proteins

L Liuxin Tu (School of Pharmaceutical Sciences) H Hong Qin (School of Pharmaceutical Sciences) S Siyuan Luo (Department of Pharmacy, The First Affiliated Hospital of University of Science and Technology of China (USTC), and School of Biomedical Engineering, Division of Life Sciences and Medicine, and Hefei National Research Center for Physical Sciences at the Microscale) X Xiaofei Liu (School of Pharmaceutical Sciences) R Ruikang Zhao (School of Life Sciences) X Xiangyan Ding (Innovation Photonics and Imaging Center, State Key Laboratory of Space Environment Interation with Matters, Key Laboratory of Ultra-Precision Intelligent Instrumentation of Ministry of Industry and Information Technology, School of Instrumentation Science and Engineering) S Shuyi Zhang (School of Pharmaceutical Sciences, State Key Laboratory of Molecular Oncology, Center for Synthetic and Systems Biology, Beijing Frontier Research Center for Biological Structure) L Ling Chu (School of Pharmaceutical Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Beijing Frontier Research Center for Biological Structure)

Article Details

Volume / Issue Vol. 147, Issue 40
Published October 08, 2025
Pages 36210-36222
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (8)

L

Liuxin Tu

School of Pharmaceutical Sciences

H

Hong Qin

School of Pharmaceutical Sciences

S

Siyuan Luo

Department of Pharmacy, The First Affiliated Hospital of University of Science and Technology of China (USTC), and School of Biomedical Engineering, Division of Life Sciences and Medicine, and Hefei National Research Center for Physical Sciences at the Microscale

X

Xiaofei Liu

School of Pharmaceutical Sciences

R

Ruikang Zhao

School of Life Sciences

X

Xiangyan Ding

Innovation Photonics and Imaging Center, State Key Laboratory of Space Environment Interation with Matters, Key Laboratory of Ultra-Precision Intelligent Instrumentation of Ministry of Industry and Information Technology, School of Instrumentation Science and Engineering

S

Shuyi Zhang

School of Pharmaceutical Sciences, State Key Laboratory of Molecular Oncology, Center for Synthetic and Systems Biology, Beijing Frontier Research Center for Biological Structure

L

Ling Chu

School of Pharmaceutical Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Beijing Frontier Research Center for Biological Structure