Ligand-Directed Site-Selective Cysteine Bioconjugation of the KELCH Domain of KEAP1 with Hypervalent Iodine Reagents

C Christine Marty (Laboratory of Catalysis and Organic Synthesis) X Xinjian Ji (Laboratory of Therapeutic Proteins and Peptides) S Stefano Nicolai (Laboratory of Catalysis and Organic Synthesis) C Christian Heinis (Laboratory of Therapeutic Proteins and Peptides) J Jerome Waser (Laboratory of Catalysis and Organic Synthesis)

Article Details

Volume / Issue Vol. 147, Issue 46
Published November 19, 2025
Pages 42524-42531
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (5)

C

Christine Marty

Laboratory of Catalysis and Organic Synthesis

X

Xinjian Ji

Laboratory of Therapeutic Proteins and Peptides

S

Stefano Nicolai

Laboratory of Catalysis and Organic Synthesis

C

Christian Heinis

Laboratory of Therapeutic Proteins and Peptides

J

Jerome Waser

Laboratory of Catalysis and Organic Synthesis