LFU-Net: LoRA-enhanced frequency-aware U-Net with recursive residual attention fusion for retinal segmentation

Z Zhongshi Wang X Xiaobing Chen Z Zhanli Wang P Peng Shao Y Yujie Luan Y Yunxia Hu X Xiulan Kang X Xue Han (State Key Laboratory of Advanced Chemical Power Sources, Frontiers Science Center for New Organic Matter, Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education), Academy for Advanced Interdisciplinary Studies, College of Chemistry) Z Zhifei Wang

Abstract

Abstract Long-tail segmentation is a crucial challenge in computer vision, where most models prioritize common head classes over rare tail classes. This problem is particularly prominent in retinal vessel segmentation, as conventional approaches often struggle to overcome underrepresented faint vessels, noise-induced boundary ambiguity, and excessive parameters that prohibit portable deployment. To address these challenges, we introduce LFU-Net, a lightweight and clinically applicable method for long-tail retinal vessel segmentation. It integrates a three-component ensemble: a Frequency-Aware Encoder with a Multi-Branch Frequency Convolution block, which uses wavelet decomposition to suppress noise and retain details; Hierarchical frequency-token enhanced Low-Rank Adaptation, which efficiently enhances the representation of tail classes (faint vessels) with minimal parameters; and a Recursive Residual Attention Fusion module to ensure vascular topological continuity. Extensive experiments on four public benchmark datasets demonstrate that LFU-Net achieves competitive performance compared to recent relevant models. Its lightweight nature supports real-time inference on portable devices. Ablation studies confirm the improvement contribution of each core component, indicating its potential utility in early disease detection when clinical resources are limited.

Article Details

Volume / Issue Vol. 16, Issue 1
Published May 02, 2026
ISSN 2045-2322
Publisher Nature Portfolio

Journal Info

Scientific Reports

Nature Portfolio

ISSN: 2045-2322 Open Access Life Sciences

Authors (9)

Z

Zhongshi Wang

X

Xiaobing Chen

Z

Zhanli Wang

P

Peng Shao

Y

Yujie Luan

Y

Yunxia Hu

X

Xiulan Kang

X

Xue Han

State Key Laboratory of Advanced Chemical Power Sources, Frontiers Science Center for New Organic Matter, Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education), Academy for Advanced Interdisciplinary Studies, College of Chemistry

Z

Zhifei Wang