Leveraging glucan-induced trained immunity for the epigenetic and metabolic rewiring of macrophages to enhance colorectal cancer vaccine response

Firas Hamdan; Sara Gandolfi; Federica D’Alessio; Yvonne Giannoula; Julia Kolikova; Manlio Fusciello; Elisa Zaghen; Alessandra Napolano; Salvatore Russo; Ozan Izci; Paolo Bottega; Jacopo Chiaro; Kirsi-Marja Alanen; Gabriella Antignani; Michaela Feodoroff; Virpi Stigzelius; Milda Sakalauskaite; Janita Sandberg; Anni I. Nieminen; Nicola Zambrano; Ove Eriksson; Satu Mustjoki; Toni T. Seppälä; Mikaela Grönholm; Vincenzo Cerullo

doi:10.1038/s41467-026-68466-5

Leveraging glucan-induced trained immunity for the epigenetic and metabolic rewiring of macrophages to enhance colorectal cancer vaccine response

F Firas Hamdan S Sara Gandolfi F Federica D’Alessio Y Yvonne Giannoula J Julia Kolikova M Manlio Fusciello E Elisa Zaghen A Alessandra Napolano S Salvatore Russo O Ozan Izci P Paolo Bottega J Jacopo Chiaro K Kirsi-Marja Alanen G Gabriella Antignani M Michaela Feodoroff V Virpi Stigzelius M Milda Sakalauskaite J Janita Sandberg A Anni I. Nieminen N Nicola Zambrano O Ove Eriksson S Satu Mustjoki T Toni T. Seppälä M Mikaela Grönholm V Vincenzo Cerullo

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Article Details

Journal Nature Communications

Volume / Issue Vol. 17, Issue 1

Published January 28, 2026

DOI 10.1038/s41467-026-68466-5

ISSN 2041-1723

Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (25)

F

Firas Hamdan

S

Sara Gandolfi

F

Federica D’Alessio

Y

Yvonne Giannoula

J

Julia Kolikova

M

Manlio Fusciello

E

Elisa Zaghen

A

Alessandra Napolano

S

Salvatore Russo

O

Ozan Izci

P

Paolo Bottega

J

Jacopo Chiaro

K

Kirsi-Marja Alanen

G

Gabriella Antignani

M

Michaela Feodoroff

V

Virpi Stigzelius

M

Milda Sakalauskaite

J

Janita Sandberg

A

Anni I. Nieminen

N

Nicola Zambrano

O

Ove Eriksson

S

Satu Mustjoki

T

Toni T. Seppälä

M

Mikaela Grönholm

V

Vincenzo Cerullo

Leveraging glucan-induced trained immunity for the epigenetic and metabolic rewiring of macrophages to enhance colorectal cancer vaccine response

Article Details

Journal Info

Authors (25)

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