Lack of association between loneliness, social isolation and inflammation in people living with HIV aged ≥50 years: Results from the sub-study “No One Alone-Gesida Study”

J Jose-Ramon Blanco H Helena Albendín-Iglesias E Eugenia Negredo-Puigmal A Ana Mª Barrios-Blandino C Cristina Tomás-Jimenez I Isabel Sanjoaquin-Conde M María Saumoy V Verónica Pérez-Esquerdo I Inmaculada Gonzalez-Cuello A Ana María López-Lirola M Maria José Galindo N Noemi Cabello-Clotet J Jesica Abadía Otero D Dolores Merino-Muñoz J Joanna Cano-Smith M Magdalena Muelas-Fernandez J Javier De La Torre A Alicia González-Baeza L Lourdes Romero A Antonio Ocampo R Rafael Torres C Carmen Hidalgo H Herminia Esteban M Maria Angeles Fernandes-López J Jordi Puig L Lucio Garcia Fraile E Enrique Bernal Morell L Laura Pérez-Martinez M Marta De Miguel Montero I Inma Jarrin J Julian Olalla

Abstract

Introduction Inflammation is linked to multiple health conditions. Emerging evidence suggest it may play a role in the association between social isolation – loneliness and health outcomes. People living with HIV (PLWH) exhibit chronic inflammation even with viral suppression, likely due to ongoing immune activation. However, few studies have explored inflammatory biomarker in PLWH experiencing loneliness or social isolation. This study aimed to assess this association in PLWH aged 50 or older.

Article Details

Journal PLoS ONE
Volume / Issue Vol. 20, Issue 12
Published December 17, 2025
Pages e0335949
ISSN 1932-6203
Publisher Public Library of Science

Journal Info

PLoS ONE

Public Library of Science

ISSN: 1932-6203 Open Access Health Sciences

Authors (31)

J

Jose-Ramon Blanco

H

Helena Albendín-Iglesias

E

Eugenia Negredo-Puigmal

A

Ana Mª Barrios-Blandino

C

Cristina Tomás-Jimenez

I

Isabel Sanjoaquin-Conde

M

María Saumoy

V

Verónica Pérez-Esquerdo

I

Inmaculada Gonzalez-Cuello

A

Ana María López-Lirola

M

Maria José Galindo

N

Noemi Cabello-Clotet

J

Jesica Abadía Otero

D

Dolores Merino-Muñoz

J

Joanna Cano-Smith

M

Magdalena Muelas-Fernandez

J

Javier De La Torre

A

Alicia González-Baeza

L

Lourdes Romero

A

Antonio Ocampo

R

Rafael Torres

C

Carmen Hidalgo

H

Herminia Esteban

M

Maria Angeles Fernandes-López

J

Jordi Puig

L

Lucio Garcia Fraile

E

Enrique Bernal Morell

L

Laura Pérez-Martinez

M

Marta De Miguel Montero

I

Inma Jarrin

J

Julian Olalla