Jorunnamycin A induces apoptosis in pancreatic ductal adenocarcinoma cells, spheroids, and patient-derived organoids by modulating KRAS-mediated survival pathways

Hnin Ei Ei Khine; Utid Suriya; Thanyada Rungrotmongkol; Supakarn Chamni; Yanxi Lu; Alan Bénard; Bin Lan; Debabrata Mukhopadhyay; David Chang; Andrew Biankin; Regine Schneider-Stock; Robert Grützmann; Rungroch Sungthong; Christian Pilarsky; Chatchai Chaotham

doi:10.1038/s41598-025-95766-5

Jorunnamycin A induces apoptosis in pancreatic ductal adenocarcinoma cells, spheroids, and patient-derived organoids by modulating KRAS-mediated survival pathways

H Hnin Ei Ei Khine U Utid Suriya T Thanyada Rungrotmongkol S Supakarn Chamni Y Yanxi Lu A Alan Bénard B Bin Lan (National Health Commission Key Laboratory of Cancer Metabolism, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital) D Debabrata Mukhopadhyay D David Chang A Andrew Biankin R Regine Schneider-Stock R Robert Grützmann R Rungroch Sungthong C Christian Pilarsky C Chatchai Chaotham

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Article Details

Journal Scientific Reports

Volume / Issue Vol. 15, Issue 1

Published April 03, 2025

DOI 10.1038/s41598-025-95766-5

ISSN 2045-2322

Publisher Nature Portfolio

Journal Info

Scientific Reports

Nature Portfolio

ISSN: 2045-2322 Open Access Life Sciences

Authors (15)

H

Hnin Ei Ei Khine

U

Utid Suriya

T

Thanyada Rungrotmongkol

S

Supakarn Chamni

Y

Yanxi Lu

A

Alan Bénard

B

Bin Lan

National Health Commission Key Laboratory of Cancer Metabolism, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital

D

Debabrata Mukhopadhyay

D

David Chang

A

Andrew Biankin

R

Regine Schneider-Stock

R

Robert Grützmann

R

Rungroch Sungthong

C

Christian Pilarsky

C

Chatchai Chaotham

Jorunnamycin A induces apoptosis in pancreatic ductal adenocarcinoma cells, spheroids, and patient-derived organoids by modulating KRAS-mediated survival pathways

Article Details

Journal Info

Authors (15)

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