Investigation of the cytotoxic effects and mechanisms of the SLC39A6-targeting ADC drug BRY812 in CRC

Xianglin Liu; Wenqiang Liu; Yuting Wu; Yichuan Wang; Qingliang Jiang; Yangyang Li; Hengyu Li; Liqiang Hao

doi:10.1038/s41598-025-03713-1

Investigation of the cytotoxic effects and mechanisms of the SLC39A6-targeting ADC drug BRY812 in CRC

X Xianglin Liu W Wenqiang Liu (State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica) Y Yuting Wu (State Key Laboratory of Precision and Intelligent Chemistry, School of Chemistry and Materials Science, and Collaborative Innovation Center of Chemistry for Energy Materials (iChEM)) Y Yichuan Wang (New Cornerstone Science Laboratory, Department of Biology, School of Life Sciences, Institute of Plant and Food Science, Southern University of Science and Technology) Q Qingliang Jiang Y Yangyang Li (Hefei National Laboratory for Physical Sciences at the Microscale, Key Laboratory of Surface and Interface Chemistry and Energy Catalysis of Anhui Higher Education Institutes, School of Chemistry and Materials Science) H Hengyu Li (Division of Chemistry and Chemical Engineering) L Liqiang Hao

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Article Details

Journal Scientific Reports

Volume / Issue Vol. 15, Issue 1

Published May 25, 2025

DOI 10.1038/s41598-025-03713-1

ISSN 2045-2322

Publisher Nature Portfolio

Journal Info

Scientific Reports

Nature Portfolio

ISSN: 2045-2322 Open Access Life Sciences

Authors (8)

X

Xianglin Liu

W

Wenqiang Liu

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica

Y

Yuting Wu

State Key Laboratory of Precision and Intelligent Chemistry, School of Chemistry and Materials Science, and Collaborative Innovation Center of Chemistry for Energy Materials (iChEM)

Y

Yichuan Wang

New Cornerstone Science Laboratory, Department of Biology, School of Life Sciences, Institute of Plant and Food Science, Southern University of Science and Technology

Q

Qingliang Jiang

Y

Yangyang Li

Hefei National Laboratory for Physical Sciences at the Microscale, Key Laboratory of Surface and Interface Chemistry and Energy Catalysis of Anhui Higher Education Institutes, School of Chemistry and Materials Science

H

Hengyu Li

Division of Chemistry and Chemical Engineering

L

Liqiang Hao

Investigation of the cytotoxic effects and mechanisms of the SLC39A6-targeting ADC drug BRY812 in CRC

Article Details

Journal Info

Authors (8)

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