Introduction to a How I Treat series on acute lymphoblastic leukemia

Abstract

Edited by Associate Editor Hervé Dombret, this How I Treat series highlights the clinical approach to high-risk subgroups of acute lymphoblastic leukemia (ALL). These include adult Philadelphia chromosome (Ph)–positive ALL, Ph-like ALL, infant acute ALL, early T-cell precursor ALL, Ph-negative ALL in older patients, and postimmunotherapy relapsed B-cell ALL. Using illustrative cases, the authors outline the approach to these patients, with recommendations with regard to targeted therapies, novel therapeutic approaches, and the changing role of allogeneic stem cell transplantation.