Intraperitoneal programming of tailored CAR macrophages via mRNA lipid nanoparticle to boost cancer immunotherapy

K Kedan Gu T Ting Liang (Department of Electronic Engineering and Materials Science and Technology Research Center) L Luting Hu Y Yifan Zhao W Weiyang Ying M Mengke Zhang (National Synchrotron Radiation Laboratory (NSRL)) Y Yashuang Chen B Benmeng Liang X Xinrui Lin (Institute of Molecular Medicine (IMM), Renji Hospital, School of Medicine, College of Chemistry and Chemical Engineering) Y Yanqi Zhang H Hongyu Wu M Meng Wang Y Yuping Zhu W Wenxi Wang (Helmholtz-Zentrum Berlin für Materialien und Energie, Hahn-Meitner-Platz 1, 14109 Berlin, Germany) Y Yu Zhang (Xiangya Hospital, Central South University Changsha China) C Chao Zuo Z Zhen Du P Penghui Zhang (Department of Clinical Laboratory, Zhejiang Cancer Hospital, The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM)) J Jia Song (Institute of Molecular Medicine (IMM), Renji Hospital, School of Medicine, College of Chemistry and Chemical Engineering) L Liwen Li (School of Petroleum Engineering) X Xiangsheng Liu S Sitao Xie W Weihong Tan (Institute of Molecular Medicine (IMM), Department of Nephrology, Molecular Cell Laboratory for Kidney Disease, Shanghai Peritoneal Dialysis Research Center, Uremia Diagnosis and Treatment Center, State Key Laboratory of Systems Medicine for Cancer, Renji Hospital, School of Medicine, School of Chemistry and Chemical Engineering)

Article Details

Volume / Issue Vol. 17, Issue 1
Published December 24, 2025
ISSN 2041-1723
Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (23)

K

Kedan Gu

T

Ting Liang

Department of Electronic Engineering and Materials Science and Technology Research Center

L

Luting Hu

Y

Yifan Zhao

W

Weiyang Ying

M

Mengke Zhang

National Synchrotron Radiation Laboratory (NSRL)

Y

Yashuang Chen

B

Benmeng Liang

X

Xinrui Lin

Institute of Molecular Medicine (IMM), Renji Hospital, School of Medicine, College of Chemistry and Chemical Engineering

Y

Yanqi Zhang

H

Hongyu Wu

M

Meng Wang

Y

Yuping Zhu

W

Wenxi Wang

Helmholtz-Zentrum Berlin für Materialien und Energie, Hahn-Meitner-Platz 1, 14109 Berlin, Germany

Y

Yu Zhang

Xiangya Hospital, Central South University Changsha China

C

Chao Zuo

Z

Zhen Du

P

Penghui Zhang

Department of Clinical Laboratory, Zhejiang Cancer Hospital, The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM)

J

Jia Song

Institute of Molecular Medicine (IMM), Renji Hospital, School of Medicine, College of Chemistry and Chemical Engineering

L

Liwen Li

School of Petroleum Engineering

X

Xiangsheng Liu

S

Sitao Xie

W

Weihong Tan

Institute of Molecular Medicine (IMM), Department of Nephrology, Molecular Cell Laboratory for Kidney Disease, Shanghai Peritoneal Dialysis Research Center, Uremia Diagnosis and Treatment Center, State Key Laboratory of Systems Medicine for Cancer, Renji Hospital, School of Medicine, School of Chemistry and Chemical Engineering