Interleukin-10 Autoantibodies and HLA-DRB1*01:03 in Inflammatory Bowel Disease

N Nima Gharahdaghi (Centre for Human Genetics, University of Oxford, Oxford, United Kingdom) P Pai-Jui Yeh (Centre for Human Genetics, University of Oxford, Oxford, United Kingdom) L Lourdes Ceron-Gutierrez (Department of Clinical Biochemistry and Immunology, Cambridge University Hospital, Cambridge, United Kingdom) H Helen Griffin (Immunity and Inflammation Theme, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom) H Hannah Gordon (Translational Gastroenterology and Liver Unit, University of Oxford, Oxford, United Kingdom) C Chamara Jayamanne (Oxford University Children’s Hospital NHS Foundation Trust, Oxford, United Kingdom) A Alice Fracchia (National Center of Excellence for Molecular Prediction of Inflammatory Bowel Disease (PREDICT), Department of Clinical Medicine, Faculty of Medicine, Aalborg University, Aalborg, Denmark) A Amanda Y. Chong (Centre for Human Genetics, University of Oxford, Oxford, United Kingdom) A Alissa Walsh (Translational Gastroenterology and Liver Unit, University of Oxford, Oxford, United Kingdom) O Oliver Brain (Translational Gastroenterology and Liver Unit, University of Oxford, Oxford, United Kingdom) K Katherine Baker H Hannah Kockelbergh (Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom) Y Yang Luo M Martha Guevara Becerra (Centre for Human Genetics, University of Oxford, Oxford, United Kingdom) K Katherine Vadakethala (Centre for Human Genetics, University of Oxford, Oxford, United Kingdom) M Madeleine Coy (Centre for Human Genetics, University of Oxford, Oxford, United Kingdom) L Ladan Kabiri (Centre for Human Genetics, University of Oxford, Oxford, United Kingdom) M Martin Barnardo (Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom) S Susanna Dunachie B Barbara Kronsteiner (NDM Centre for Global Health Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom) A Anna Adams (Translational Gastroenterology and Liver Unit, University of Oxford, Oxford, United Kingdom) D Darren Fowler (Department of Pathology, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom) Q Qian Zhang L Laura Fachal C Carl A. Anderson R Rofaida Desoki (Genomics of Inflammation and Immunity Group, Human Genetics Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom) M Marie Vibeke Vestergaard (National Center of Excellence for Molecular Prediction of Inflammatory Bowel Disease (PREDICT), Department of Clinical Medicine, Faculty of Medicine, Aalborg University, Aalborg, Denmark) L Lone Larsen (National Center of Excellence for Molecular Prediction of Inflammatory Bowel Disease (PREDICT), Department of Clinical Medicine, Faculty of Medicine, Aalborg University, Aalborg, Denmark) N Nicola J. Wyatt (Immunity and Inflammation Theme, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom) R Robert D. Lees (Immunity and Inflammation Theme, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom) R Robert J. Mulligan (Immunity and Inflammation Theme, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom) C Chaonan Dong (Immunity and Inflammation Theme, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom) M Mohmmed Tauseef Sharip (Cambridge University Hospitals, Cambridge, United Kingdom) S Siân E. Faustini (Clinical Immunology Services, University of Birmingham, Birmingham, United Kingdom) A Adrian Shields (Clinical Immunology Services, University of Birmingham, Birmingham, United Kingdom) J Julia Pakpoor (Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom) B Bushra Naz (Centre for Human Genetics, University of Oxford, Oxford, United Kingdom) A Alex Richter (Clinical Immunology Services, University of Birmingham, Birmingham, United Kingdom) J Jack Satsangi (Centre for Human Genetics, University of Oxford, Oxford, United Kingdom) C Christopher A. Lamb (Immunity and Inflammation Theme, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom) M Miles Parkes F Fiona Powrie (Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom) A Alexander J. Mentzer (Centre for Human Genetics, University of Oxford, Oxford, United Kingdom) A Aleksejs Sazonovs (National Center of Excellence for Molecular Prediction of Inflammatory Bowel Disease (PREDICT), Department of Clinical Medicine, Faculty of Medicine, Aalborg University, Aalborg, Denmark) T Tine Jess (National Center of Excellence for Molecular Prediction of Inflammatory Bowel Disease (PREDICT), Department of Clinical Medicine, Faculty of Medicine, Aalborg University, Aalborg, Denmark) P Paul Klenerman (Translational Gastroenterology and Liver Unit, University of Oxford, Oxford, United Kingdom) S Simon Travis (Translational Gastroenterology and Liver Unit, University of Oxford, Oxford, United Kingdom) S Sophie Hambleton R Rainer Doffinger (Department of Clinical Biochemistry and Immunology, Cambridge University Hospital, Cambridge, United Kingdom) H Holm H. Uhlig (Centre for Human Genetics, University of Oxford, Oxford, United Kingdom)

Article Details

Volume / Issue Vol. 394, Issue 22
Published June 11, 2026
Pages 2212-2222
ISSN 0028-4793
Publisher Massachusetts Medical Society

Journal Info

New England Journal of Medicine

Massachusetts Medical Society

ISSN: 0028-4793 Social Sciences

Authors (50)

N

Nima Gharahdaghi

Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

P

Pai-Jui Yeh

Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

L

Lourdes Ceron-Gutierrez

Department of Clinical Biochemistry and Immunology, Cambridge University Hospital, Cambridge, United Kingdom

H

Helen Griffin

Immunity and Inflammation Theme, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom

H

Hannah Gordon

Translational Gastroenterology and Liver Unit, University of Oxford, Oxford, United Kingdom

C

Chamara Jayamanne

Oxford University Children’s Hospital NHS Foundation Trust, Oxford, United Kingdom

A

Alice Fracchia

National Center of Excellence for Molecular Prediction of Inflammatory Bowel Disease (PREDICT), Department of Clinical Medicine, Faculty of Medicine, Aalborg University, Aalborg, Denmark

A

Amanda Y. Chong

Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

A

Alissa Walsh

Translational Gastroenterology and Liver Unit, University of Oxford, Oxford, United Kingdom

O

Oliver Brain

Translational Gastroenterology and Liver Unit, University of Oxford, Oxford, United Kingdom

K

Katherine Baker

H

Hannah Kockelbergh

Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom

Y

Yang Luo

M

Martha Guevara Becerra

Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

K

Katherine Vadakethala

Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

M

Madeleine Coy

Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

L

Ladan Kabiri

Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

M

Martin Barnardo

Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom

S

Susanna Dunachie

B

Barbara Kronsteiner

NDM Centre for Global Health Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom

A

Anna Adams

Translational Gastroenterology and Liver Unit, University of Oxford, Oxford, United Kingdom

D

Darren Fowler

Department of Pathology, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom

Q

Qian Zhang

L

Laura Fachal

C

Carl A. Anderson

R

Rofaida Desoki

Genomics of Inflammation and Immunity Group, Human Genetics Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom

M

Marie Vibeke Vestergaard

National Center of Excellence for Molecular Prediction of Inflammatory Bowel Disease (PREDICT), Department of Clinical Medicine, Faculty of Medicine, Aalborg University, Aalborg, Denmark

L

Lone Larsen

National Center of Excellence for Molecular Prediction of Inflammatory Bowel Disease (PREDICT), Department of Clinical Medicine, Faculty of Medicine, Aalborg University, Aalborg, Denmark

N

Nicola J. Wyatt

Immunity and Inflammation Theme, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom

R

Robert D. Lees

Immunity and Inflammation Theme, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom

R

Robert J. Mulligan

Immunity and Inflammation Theme, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom

C

Chaonan Dong

Immunity and Inflammation Theme, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom

M

Mohmmed Tauseef Sharip

Cambridge University Hospitals, Cambridge, United Kingdom

S

Siân E. Faustini

Clinical Immunology Services, University of Birmingham, Birmingham, United Kingdom

A

Adrian Shields

Clinical Immunology Services, University of Birmingham, Birmingham, United Kingdom

J

Julia Pakpoor

Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom

B

Bushra Naz

Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

A

Alex Richter

Clinical Immunology Services, University of Birmingham, Birmingham, United Kingdom

J

Jack Satsangi

Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

C

Christopher A. Lamb

Immunity and Inflammation Theme, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom

M

Miles Parkes

F

Fiona Powrie

Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom

A

Alexander J. Mentzer

Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

A

Aleksejs Sazonovs

National Center of Excellence for Molecular Prediction of Inflammatory Bowel Disease (PREDICT), Department of Clinical Medicine, Faculty of Medicine, Aalborg University, Aalborg, Denmark

T

Tine Jess

National Center of Excellence for Molecular Prediction of Inflammatory Bowel Disease (PREDICT), Department of Clinical Medicine, Faculty of Medicine, Aalborg University, Aalborg, Denmark

P

Paul Klenerman

Translational Gastroenterology and Liver Unit, University of Oxford, Oxford, United Kingdom

S

Simon Travis

Translational Gastroenterology and Liver Unit, University of Oxford, Oxford, United Kingdom

S

Sophie Hambleton

R

Rainer Doffinger

Department of Clinical Biochemistry and Immunology, Cambridge University Hospital, Cambridge, United Kingdom

H

Holm H. Uhlig

Centre for Human Genetics, University of Oxford, Oxford, United Kingdom