Insights from patients with early-stage, hormone positive breast cancer (BC) using an artificial intelligence (AI)–driven digital navigation platform.

Abstract

e12554 Background: Patients with BC navigate complex treatment decisions influenced by tumor biology, disease extent, and personal values. Early-stage hormone receptor-positive BC, the most common subtype, involves multi-year hormone therapy decisions. We examined how an AI-powered navigation platform supports BC patients in understanding their diagnosis, treatment and side effect management options. Methods: We used Claude Sonnet 4.5 to analyze patient-initiated conversations with the Manta Cares platform (ASCO 2025 Abst e13713),which includes a multistation cancer map and a “fenced garden” AI tool. We characterized conversation themes, treatment-related queries, and indicators of patient empowerment in clinical decision-making. Results: From 11/27/2025 through 1/26/2026 we analyzed 20 patient conversation threads originating with patients aged 40-75 years. Themes are ordered in the table starting with most common. Conclusions: An AI-powered digital navigation platform has utility for early stage BC patients seeking to understand their treatment and side effect management options. By delivering subtype-tailored guidance, the Manta Cares platform addresses knowledge gaps that undermine confidence in treatment decisions. This approach may enhance shared decision-making and patient engagement in their breast cancer care, particularly for complex decisions surrounding long-term endocrine therapy adherence. Oncologists and their teams should address these concerns early and continuously in the patient’s course. Conversation Theme Conversation Description User Impact Hormone therapy side effects Hot flashes, joint pain, fatigue, mood changes, vaginal dryness Affects quality of life and treatment adherence Emotional Health Depression, anxiety, fear of recurrence, post-treatment adjustment Common 5+ months post-treatment; often unpredictable waves Sexual/relationship impact Libido changes, early menopause effects Long-term concern given 5-10 year treatment duration Treatment decisions Understanding test results, receptor status, why hormone therapy needed Users need clarity on estrogen and progesterone receptor positive implications Treatment duration concerns Tolerating 5-10 years of therapy Balancing prevention benefits vs. quality of life Healthcare navigation Coordinating specialists, preparing appointments Need for symptom tracking and communication tools