Inhibitor-Dependent Tolerance of New Delhi Metallo-β-Lactamase Driven by Single Mutation-Induced Conformational Changes

L Liwen Huang (Department of Applied Biology and Chemical Technology, Food Safety and Technology Research Centre, and Research Centre for Chinese Medicine Innovation, The Hong Kong Polytechnic University, Hung Hom, Kowloon 999077, Hong Kong SAR, China) T Tsz-Fung Wong (Department of Applied Biology and Chemical Technology, Food Safety and Technology Research Centre, and Research Centre for Chinese Medicine Innovation, The Hong Kong Polytechnic University, Hung Hom, Kowloon 999077, Hong Kong SAR, China) Q Qipeng Cheng (State Key Laboratory of Chinese Medicine and Molecular Pharmacology (Incubation), and Shenzhen Key Laboratory of Food Biological Safety Control) P Pui-Kin So (University Research Facility in Life Sciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon 999077, Hong Kong SAR, China) M Ming Liu X Xuechen Li (Department of Chemistry, State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, Hong Kong SAR 999077, P. R. China) S Sheng Chen (Beijing Frontier Research Center for Biological Structures, State Key Laboratory of Membrane Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China.) Z Zhong-Ping Yao (Department of Applied Biology and Chemical Technology, Food Safety and Technology Research Centre, and Research Centre for Chinese Medicine Innovation, The Hong Kong Polytechnic University, Hung Hom, Kowloon 999077, Hong Kong SAR, China)

Article Details

Volume / Issue Vol. 147, Issue 30
Published July 30, 2025
Pages 26389-26401
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (8)

L

Liwen Huang

Department of Applied Biology and Chemical Technology, Food Safety and Technology Research Centre, and Research Centre for Chinese Medicine Innovation, The Hong Kong Polytechnic University, Hung Hom, Kowloon 999077, Hong Kong SAR, China

T

Tsz-Fung Wong

Department of Applied Biology and Chemical Technology, Food Safety and Technology Research Centre, and Research Centre for Chinese Medicine Innovation, The Hong Kong Polytechnic University, Hung Hom, Kowloon 999077, Hong Kong SAR, China

Q

Qipeng Cheng

State Key Laboratory of Chinese Medicine and Molecular Pharmacology (Incubation), and Shenzhen Key Laboratory of Food Biological Safety Control

P

Pui-Kin So

University Research Facility in Life Sciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon 999077, Hong Kong SAR, China

M

Ming Liu

X

Xuechen Li

Department of Chemistry, State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, Hong Kong SAR 999077, P. R. China

S

Sheng Chen

Beijing Frontier Research Center for Biological Structures, State Key Laboratory of Membrane Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China.

Z

Zhong-Ping Yao

Department of Applied Biology and Chemical Technology, Food Safety and Technology Research Centre, and Research Centre for Chinese Medicine Innovation, The Hong Kong Polytechnic University, Hung Hom, Kowloon 999077, Hong Kong SAR, China