Induced Molecular Orientation Transition via Organic‐Inorganic Hybrid Networks in Thin‐Film Transistor‐Based Biosensors

Abstract

ABSTRACT Molecular orientation transition is a key determinant of charge transport efficiency in thin‐film transistors (TFTs). Conventional strategies to induce such transitions often result in increased molecular disorder, which leads to device performance degradation. Herein, an organic‐inorganic hybrid network was proposed to modulate the structure‐performance relationship via the incorporation of specific inorganic metal oxides (e.g., In 2 O 3 ), leading to a marked enhancement in device and sensing performance by nearly 20‐fold. This phenomenon may be associated with a triple‐condition mechanistic framework involving strong interfacial adsorption, thermodynamic driving force, and abundant oxygen vacancies. The proposed triple‐condition mechanistic framework not only transforms molecular orientation from observation into a predictable rule for selecting inorganic additives in organic‐inorganic hybrid networks, but also establishes a practical route for improving biosensing performance through molecular orientation in life and health monitoring.