Increased local DNA methylation disorder in AMLs with DNMT3A-destabilizing variants and its clinical implication

Dohoon Lee

Bonil Koo

Seokhyeon Kim

Jamin Byun

Junshik Hong

Dong-Yeop Shin

Choong-Hyun Sun

Jaesung Kim

Ji-Joon Song

Siddhartha Jaiswal

Sung-Soo Yoon

From Tel Aviv Sourasky Medical Center (Y.C.C., I.A.), and the Faculty of Medical and Health Sciences, Tel Aviv University (Y.C.C., H.M., I.A.), Tel Aviv, Chaim Sheba Medical Center, Ramat Gan (H.M.), and Hadassah Hebrew University Medical Center, Jerusalem (M.G.) — all in Israel; McGill University and McGill University Health Centre, Montreal (M.S.), and Alberta Health Services, Edmonton (M.P.C.) — all in Canada; Samsung Medical Center, Sungkyunkwan University School of Medicine (K.K.), Seoul St. Mary’s Hospital, Catholic University of Korea (C.-K.M.), and Seoul National University College of Medicine (S.-S.Y.) — all in Seoul, South Korea; Hospital Universitario Marqués de Valdecilla, Instituto de Investigación Sanitaria Valdecilla, Universidad de Cantabria, Santander (E.M.O.), Cancer Center Clínica Universidad de Navarra, Center for Applied Medical Research, Pamplona (P.R.-O.), Institut Català d’Oncologia, Josep Carreras Leukemia Research Institute, and the Hospital Germans Trias i Pujol, Barcelona (A.O.)...

Sun Kim

Youngil Koh

Seoul National University Hospital, Seoul National University, Jongno-gu, Seoul, South Korea