In vivo antitumor activity of doxorubicin loaded on chitosan functionalized Pb2Mn2Fe12O22 magnetic nanoparticles

Abstract

Abstract Nanoscale materials can improve cancer treatment by safely and efficiently delivering chemotherapeutic drugs. This study was designated to load the anticancer drug doxorubicin (DOX) into chitosan-coated Pb2Mn2Fe12O22 magnetic nanoparticles (CT-MNPs) and compare their physicochemical and biological effects with free drug, in addition to the therapeutic role of DOX-CT-MNPs to acting efficaciously in restraint of cancer cells growth and evolution using Ehrlich solid tumor model (EST). Forty female mice were randomly and equally split into four groups (EST; EST + Free DOX; EST + CT-MNPs; and EST + DOX-CT-MNPs). Our findings show that treating EST with DOX, either free or loaded on CT-MNPs, inhibits tumour growth by producing oxidative stress, disrupting the antioxidant system, activating apoptosis, and arresting the cell cycle. Furthermore, DOX loaded on CT-MNPs had greater anticancer activity than DOX in its free form. This highlights the potential advantages of CT-MNPs in tumour therapy and drug delivery.