In-situ cross-linking mass spectrometry reveals compartment-specific proteasomal interactions and structural heterogeneity

L Lili Zhao (Engineering Research Center of Ministry of Education for Fine Chemicals) R Runtao Zhao Z Zhou Gong (State Key Laboratory of Magnetic Resonance Spectroscopy and Imaging, National Center for Magnetic Resonance in Wuhan, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences) F Fuxiang Liang N Nan Zhao (Shenzhen Institute for Quantum Science and Engineering, Department of Chemistry, and Department of Physics) B Bowen Zhong M Maili Liu (State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, National Center for Magnetic Resonance in Wuhan, Innovation Academy for Precision Measurement Science and Technology) Y Yukui Zhang Q Qun Zhao (State Key Laboratory of Medical Proteomics, National Chromatographic Research & Analysis Center, Chinese Academy of Sciences Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences) L Lihua Zhang (Center for Functional Nanomaterials) C Chun Tang (College of Materials & State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering & IKKEM)

Article Details

Volume / Issue Vol. 16, Issue 1
Published November 28, 2025
ISSN 2041-1723
Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (11)

L

Lili Zhao

Engineering Research Center of Ministry of Education for Fine Chemicals

R

Runtao Zhao

Z

Zhou Gong

State Key Laboratory of Magnetic Resonance Spectroscopy and Imaging, National Center for Magnetic Resonance in Wuhan, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences

F

Fuxiang Liang

N

Nan Zhao

Shenzhen Institute for Quantum Science and Engineering, Department of Chemistry, and Department of Physics

B

Bowen Zhong

M

Maili Liu

State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, National Center for Magnetic Resonance in Wuhan, Innovation Academy for Precision Measurement Science and Technology

Y

Yukui Zhang

Q

Qun Zhao

State Key Laboratory of Medical Proteomics, National Chromatographic Research & Analysis Center, Chinese Academy of Sciences Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences

L

Lihua Zhang

Center for Functional Nanomaterials

C

Chun Tang

College of Materials & State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering & IKKEM