Impact of HLA alloimmunization in gene-modified autologous stem cell transplant for transfusion-dependent thalassemia
Abstract
Abstract We report our single-center experience demonstrating that HLA class I alloimmunization predicts longer time to platelet engraftment, increased bleeding complications, and higher transfusion requirements in patients undergoing gene-modified hematopoietic stem cell transplant for transfusion-dependent β thalassemia.
Article Details
Authors (8)
Nora M. Gibson
1Cell Therapy and Transplant Section, Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA
Eugene Khandros
1Division of Hematology, Children’s Hospital of Philadelphia, Philadelphia, PA
Caitlin W. Elgarten
1Cell Therapy and Transplant Section, Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA
Elizabeth Worster
3Children's Hospital of Philadelphia, Cell Therapy and Transplant Section, Division of Oncology, Department of Pediatrics, Philadelphia, United States
Dimitrios S. Monos
3Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA
Alexis A. Thompson
Children’s Hospital of Philadelphia, Philadelphia
Janet L. Kwiatkowski
1Division of Hematology, Children’s Hospital of Philadelphia, Philadelphia, PA
Timothy S. Olson
1Division of Hematology, Children’s Hospital of Philadelphia, Philadelphia, PA