IL-17RA signaling promotes the dedifferentiation of Paneth progenitors through ADAM17 to regenerate gut epithelium post-irradiation

Cody G. Kempen; Ankita Singh; Keith A. Breau; Hafiz I. Tariq; Yangle Yu; Stephen J. Gaudino; Tej Bahadur; Emilia Orzechowska-Licari; Onur Eskiocak; Kiyoshi Shiomitsu; Richard Blumberg; Paula Denoya; Rebecca Martin; Agnieszka B. Bialkowska; Semir Beyaz; Scott T. Magness; Patrick Hearing; Hwan Keun Kim; Brian S. Sheridan; Peter Dempsey; Pawan Kumar

doi:10.1038/s41467-026-70479-z

IL-17RA signaling promotes the dedifferentiation of Paneth progenitors through ADAM17 to regenerate gut epithelium post-irradiation

C Cody G. Kempen A Ankita Singh K Keith A. Breau H Hafiz I. Tariq Y Yangle Yu S Stephen J. Gaudino T Tej Bahadur E Emilia Orzechowska-Licari O Onur Eskiocak K Kiyoshi Shiomitsu R Richard Blumberg P Paula Denoya R Rebecca Martin A Agnieszka B. Bialkowska S Semir Beyaz S Scott T. Magness P Patrick Hearing H Hwan Keun Kim B Brian S. Sheridan P Peter Dempsey P Pawan Kumar

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Article Details

Journal Nature Communications

Volume / Issue Vol. 17, Issue 1

Published March 17, 2026

DOI 10.1038/s41467-026-70479-z

ISSN 2041-1723

Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (21)

C

Cody G. Kempen

A

Ankita Singh

K

Keith A. Breau

H

Hafiz I. Tariq

Y

Yangle Yu

S

Stephen J. Gaudino

T

Tej Bahadur

E

Emilia Orzechowska-Licari

O

Onur Eskiocak

K

Kiyoshi Shiomitsu

R

Richard Blumberg

P

Paula Denoya

R

Rebecca Martin

A

Agnieszka B. Bialkowska

S

Semir Beyaz

S

Scott T. Magness

P

Patrick Hearing

H

Hwan Keun Kim

B

Brian S. Sheridan

P

Peter Dempsey

P

Pawan Kumar

IL-17RA signaling promotes the dedifferentiation of Paneth progenitors through ADAM17 to regenerate gut epithelium post-irradiation

Article Details

Journal Info

Authors (21)

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