Identification of Actionable Targeted Protein Degradation Effector Sites through Site-Specific Ligand Incorporation-Induced Proximity (SLIP)

Z Zhangping Xiao (Department of Chemistry, Molecular Sciences Research Hub) E Efthymios S. Gavriil (Department of Chemistry, Imperial College London, 82 Wood Lane, London W12 0BZ, U.K.) F Fangyuan Cao (Department of Chemistry, Imperial College London, 82 Wood Lane, London W12 0BZ, U.K.) X Xinyue Zhang S Stan Xiaogang Li (Center for the Advanced Study of Drug Action, Department of Chemistry) S Sergei Kotelnikov (Department of Applied Mathematics and Statistics) P Patrycja Michalska (Department of Chemistry, Imperial College London, 82 Wood Lane, London W12 0BZ, U.K.) F Friederike Marte (Department of Chemistry, Imperial College London, 82 Wood Lane, London W12 0BZ, U.K.) C Chloe Huang (Department of Chemistry, Imperial College London, 82 Wood Lane, London W12 0BZ, U.K.) Y Yudi Lu (Department of Chemistry, Imperial College London, 82 Wood Lane, London W12 0BZ, U.K.) Y Yunxuan Zhang (Department of Chemistry, Imperial College London, 82 Wood Lane, London W12 0BZ, U.K.) E Erika Bernardini (Department of Chemistry, Imperial College London, 82 Wood Lane, London W12 0BZ, U.K.) D Dima Kozakov (Laufer Center for Physical and Quantitative Biology) E Edward W. Tate

Article Details

Volume / Issue Vol. 147, Issue 25
Published June 25, 2025
Pages 21549-21559
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (14)

Z

Zhangping Xiao

Department of Chemistry, Molecular Sciences Research Hub

E

Efthymios S. Gavriil

Department of Chemistry, Imperial College London, 82 Wood Lane, London W12 0BZ, U.K.

F

Fangyuan Cao

Department of Chemistry, Imperial College London, 82 Wood Lane, London W12 0BZ, U.K.

X

Xinyue Zhang

S

Stan Xiaogang Li

Center for the Advanced Study of Drug Action, Department of Chemistry

S

Sergei Kotelnikov

Department of Applied Mathematics and Statistics

P

Patrycja Michalska

Department of Chemistry, Imperial College London, 82 Wood Lane, London W12 0BZ, U.K.

F

Friederike Marte

Department of Chemistry, Imperial College London, 82 Wood Lane, London W12 0BZ, U.K.

C

Chloe Huang

Department of Chemistry, Imperial College London, 82 Wood Lane, London W12 0BZ, U.K.

Y

Yudi Lu

Department of Chemistry, Imperial College London, 82 Wood Lane, London W12 0BZ, U.K.

Y

Yunxuan Zhang

Department of Chemistry, Imperial College London, 82 Wood Lane, London W12 0BZ, U.K.

E

Erika Bernardini

Department of Chemistry, Imperial College London, 82 Wood Lane, London W12 0BZ, U.K.

D

Dima Kozakov

Laufer Center for Physical and Quantitative Biology

E

Edward W. Tate