Identification of a non-inhibitory aptameric ligand to CRL2ZYG11B E3 ligase for targeted protein degradation

Z Zhihao Yang M Miao Chen (Department of Chemistry) R Ruixin Ge P Ping Zhou W Wei Pan J Jiayi Song (Innovation Research Center for AIE Pharmaceutical Biology, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, The NMPA and State Key Laboratory of Respiratory Disease, and School of Pharmaceutical Sciences) S Shuwen Ma S Song Chen (Department of Applied Physics, School of Medical Imaging) C Chenyu Xu M Mengyu Zhou W Wenyi Mi H Hua Ni H He Chen (Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences, Oncological Sciences and Neuroscience, Tisch Cancer Institute) X Xue Yao (Department of Materials Science and Engineering) X Xifeng Dong Y Yan Chen J Jun Zhou C Chenghao Xuan C Cheng Dong (Beijing National Laboratory for Condensed Matter Physics) H Hua Yan S Songbo Xie