Journal of the American Chemical Society

Identification of a Highly Cooperative PROTAC Degrader Targeting GTP-Loaded KRAS(On) Alleles

V Vesna Vetma (Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, 1 James Lindsay Place, DD1 5JJ Dundee, Scotland, U.K.) I Ilaria Puoti (Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, 1 James Lindsay Place, DD1 5JJ Dundee, Scotland, U.K.) N Natalia K. Karolak (Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, 1 James Lindsay Place, DD1 5JJ Dundee, Scotland, U.K.) S Sohini Chakraborti (Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, 1 James Lindsay Place, DD1 5JJ Dundee, Scotland, U.K.) E Emelyne Diers (Division of Biological Chemistry and Drug Discovery, School of Life Sciences, James Black Centre) E Enrico Girardi (Boehringer Ingelheim RCV GmbH & Co KG) S Shakil Khan (Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, 1 James Lindsay Place, DD1 5JJ Dundee, Scotland, U.K.) G Giorgia Kidd (Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, 1 James Lindsay Place, DD1 5JJ Dundee, Scotland, U.K.) K Katrin G. Kropatsch (Boehringer Ingelheim RCV GmbH & Co KG) R Ross Mclennan (Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, 1 James Lindsay Place, DD1 5JJ Dundee, Scotland, U.K.) S Suzanne O’Connor (Centre for Targeted Protein Degradation, School of Life Sciences) M Matthias Samwer (Boehringer Ingelheim RCV GmbH & Co KG) N Nicole Trainor (Division of Biological Chemistry and Drug Discovery, School of Life Sciences, James Black Centre) C Claire Whitworth (Division of Biological Chemistry and Drug Discovery, School of Life Sciences, James Black Centre) A Andre J. Wijaya J Jeff Y. F. Wong (Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, 1 James Lindsay Place, DD1 5JJ Dundee, Scotland, U.K.) D David Zollman (Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, 1 James Lindsay Place, DD1 5JJ Dundee, Scotland, U.K.) W William Farnaby (Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, 1 James Lindsay Place, DD1 5JJ Dundee, Scotland, U.K.) J Johannes Popow (Boehringer Ingelheim RCV GmbH & Co KG) A Alessio Ciulli (Centre for Targeted Protein Degradation, School of Life Sciences) P Peter Ettmayer (Boehringer Ingelheim RCV GmbH & Co KG) K Kirsten McAulay (Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, 1 James Lindsay Place, DD1 5JJ Dundee, Scotland, U.K.)
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Article Details

Volume / Issue Vol. 147, Issue 45
Published November 12, 2025
Pages 41367-41378
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society
ISSN: 0002-7863 Physical Sciences

Authors (22)

V

Vesna Vetma

Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, 1 James Lindsay Place, DD1 5JJ Dundee, Scotland, U.K.

I

Ilaria Puoti

Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, 1 James Lindsay Place, DD1 5JJ Dundee, Scotland, U.K.

N

Natalia K. Karolak

Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, 1 James Lindsay Place, DD1 5JJ Dundee, Scotland, U.K.

S

Sohini Chakraborti

Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, 1 James Lindsay Place, DD1 5JJ Dundee, Scotland, U.K.

E

Emelyne Diers

Division of Biological Chemistry and Drug Discovery, School of Life Sciences, James Black Centre

E

Enrico Girardi

Boehringer Ingelheim RCV GmbH & Co KG

S

Shakil Khan

Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, 1 James Lindsay Place, DD1 5JJ Dundee, Scotland, U.K.

G

Giorgia Kidd

Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, 1 James Lindsay Place, DD1 5JJ Dundee, Scotland, U.K.

K

Katrin G. Kropatsch

Boehringer Ingelheim RCV GmbH & Co KG

R

Ross Mclennan

Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, 1 James Lindsay Place, DD1 5JJ Dundee, Scotland, U.K.

S

Suzanne O’Connor

Centre for Targeted Protein Degradation, School of Life Sciences

M

Matthias Samwer

Boehringer Ingelheim RCV GmbH & Co KG

N

Nicole Trainor

Division of Biological Chemistry and Drug Discovery, School of Life Sciences, James Black Centre

C

Claire Whitworth

Division of Biological Chemistry and Drug Discovery, School of Life Sciences, James Black Centre

A

Andre J. Wijaya

J

Jeff Y. F. Wong

Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, 1 James Lindsay Place, DD1 5JJ Dundee, Scotland, U.K.

D

David Zollman

Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, 1 James Lindsay Place, DD1 5JJ Dundee, Scotland, U.K.

W

William Farnaby

Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, 1 James Lindsay Place, DD1 5JJ Dundee, Scotland, U.K.

J

Johannes Popow

Boehringer Ingelheim RCV GmbH & Co KG

A

Alessio Ciulli

Centre for Targeted Protein Degradation, School of Life Sciences

P

Peter Ettmayer

Boehringer Ingelheim RCV GmbH & Co KG

K

Kirsten McAulay

Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, 1 James Lindsay Place, DD1 5JJ Dundee, Scotland, U.K.

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