Hypertrophic cardiomyopathy mutations Y115H and E497D disrupt the folded-back state of human β-cardiac myosin allosterically

N Neha Nandwani (Department of Biochemistry, Stanford University School of Medicine) D Debanjan Bhowmik C Camille Glaser M Matthew Carter Childers R Rama Reddy Goluguri (Department of Biochemistry, Stanford University School of Medicine) A Aminah Dawood (Department of Biochemistry, Stanford University School of Medicine) M Michael Regnier A Anne Houdusse (Structural Motility, Institut Curie, Université Paris Sciences et Lettres, Sorbonne Université, CNRS UMR144) J James A. Spudich (Department of Biochemistry, Stanford University School of Medicine) K Kathleen M. Ruppel (Department of Biochemistry, Stanford University School of Medicine)

Article Details

Volume / Issue Vol. 16, Issue 1
Published October 01, 2025
ISSN 2041-1723
Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (10)

N

Neha Nandwani

Department of Biochemistry, Stanford University School of Medicine

D

Debanjan Bhowmik

C

Camille Glaser

M

Matthew Carter Childers

R

Rama Reddy Goluguri

Department of Biochemistry, Stanford University School of Medicine

A

Aminah Dawood

Department of Biochemistry, Stanford University School of Medicine

M

Michael Regnier

A

Anne Houdusse

Structural Motility, Institut Curie, Université Paris Sciences et Lettres, Sorbonne Université, CNRS UMR144

J

James A. Spudich

Department of Biochemistry, Stanford University School of Medicine

K

Kathleen M. Ruppel

Department of Biochemistry, Stanford University School of Medicine