Hydrophobic Refinement of Polarity-Switchable Lipo-Xenopeptides Modulates Endosomal Escape and Enhances mRNA Delivery In Vitro and In Vivo

T Tobias Burghardt (Pharmaceutical Biotechnology, Department of Pharmacy) S Sophie Thalmayr (Pharmaceutical Biotechnology, Department of Pharmacy) L Lennart Obeser (Pharmaceutical Chemistry, Department of Pharmacy) J Jana Pöhmerer (Pharmaceutical Biotechnology, Department of Pharmacy) M Mina Yazdi (Pharmaceutical Biotechnology, Department of Pharmacy) M Miriam Höhn (Pharmaceutical Biotechnology, Department of Pharmacy) M Matthias Völkl (Pharmaceutical Biology, Department of Pharmacy) F Felix Sieber-Schäfer (Pharmaceutical Technology and Biopharmaceutics, Department of Pharmacy) S Stefan Zahler (Pharmaceutical Biology, Department of Pharmacy) O Olivia M. Merkel (Center for NanoScience (CeNS)) D Daniel Merk (Pharmaceutical Chemistry, Department of Pharmacy) E Ernst Wagner (Pharmaceutical Biotechnology, Department of Pharmacy)

Article Details

Volume / Issue Vol. 148, Issue 9
Published March 11, 2026
Pages 9449-9464
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (12)

T

Tobias Burghardt

Pharmaceutical Biotechnology, Department of Pharmacy

S

Sophie Thalmayr

Pharmaceutical Biotechnology, Department of Pharmacy

L

Lennart Obeser

Pharmaceutical Chemistry, Department of Pharmacy

J

Jana Pöhmerer

Pharmaceutical Biotechnology, Department of Pharmacy

M

Mina Yazdi

Pharmaceutical Biotechnology, Department of Pharmacy

M

Miriam Höhn

Pharmaceutical Biotechnology, Department of Pharmacy

M

Matthias Völkl

Pharmaceutical Biology, Department of Pharmacy

F

Felix Sieber-Schäfer

Pharmaceutical Technology and Biopharmaceutics, Department of Pharmacy

S

Stefan Zahler

Pharmaceutical Biology, Department of Pharmacy

O

Olivia M. Merkel

Center for NanoScience (CeNS)

D

Daniel Merk

Pharmaceutical Chemistry, Department of Pharmacy

E

Ernst Wagner

Pharmaceutical Biotechnology, Department of Pharmacy