How ketamine works: An actionable hypothesis
R
Roberto Malinow
(Department of Neurosciences and Section of Neurobiology, University of California at San Diego)
Abstract
Ketamine has been shown to reduce depression and suicidality in individuals resistant to treatment by other drugs. Exactly how ketamine works is not known. Here, I propose a new hypothesis that involves synaptic and circuit plasticity and may lead to enhanced efficacy in treating depression as well as other conditions.
Article Details
Volume / Issue
Vol. 123, Issue 18
Published
May 05, 2026
ISSN
0027-8424
Publisher
National Academy of Sciences
Journal Info
Proceedings of the National Academy of Sciences
National Academy of Sciences
ISSN: 0027-8424 Life Sciences
Authors (1)
R
Roberto Malinow
Department of Neurosciences and Section of Neurobiology, University of California at San Diego
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