Host-microbe multiomic profiling identifies distinct COVID-19 immune dysregulation in solid organ transplant recipients

J Joanna Schaenman H Hoang Van Phan A Alexandra Tsitsiklis N Nadine Rouphael N Nelson Iván Agudelo Higuita M Mark A. Atkinson S Scott Brakenridge M Monica Fung W William Messer A Adreanne M. Rivera H Harry Pickering S Subha Sen D David Elashoff D Dawn C. Ward J Jenny Brook E Estefania Ramires-Sanchez M Megan Llamas C Claudia Perdomo C Clara E. Magyar (Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California at Los Angeles) J Jennifer Fulcher D David J. Erle C Carolyn S. Calfee C Carolyn M. Hendrickson K Kirsten N. Kangelaris V Viet Nguyen D Deanna Lee S Suzanna Chak R Rajani Ghale A Ana Gonzalez A Alejandra Jauregui C Carolyn Leroux L Luz Torres Altamirano A Ahmad Sadeed Rashid A Andrew Willmore P Prescott G. Woodruff (Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, School of Medicine, University of California, San Francisco, San Francisco, CA, USA.) M Matthew F. Krummel S Sidney Carrillo A Alyssa Ward R Ravi Patel M Michael Wilson R Ravi Dandekar B Bonny Alvarenga J Jayant Rajan A Andrew W. Schroeder G Gabriela K. Fragiadakis E Eran Mick Y Yanedth Sanchez Guerrero C Christina Love L Lenka Maliskova M Michael Adkisson A Aleksandra Leligdowicz A Alexander Beagle A Arjun Rao (Department of Emergency Medicine, Sydney Children’s Hospital, Randwick, NSW, Australia) A Austin Sigman B Bushra Samad C Cindy Curiel C Cole Shaw G Gayelan Tietje-Ulrich J Jeff Milush J Jonathan Singer J Joshua J. Vasquez K Kevin Tang L Legna Betancourt L Lekshmi Santhosh L Logan Pierce M Maria Tecero Paz M Michael M. Matthay N Neeta Thakur N Nicklaus Rodriguez N Nicole Sutter N Norman Jones P Pratik Sinha P Priya Prasad R Raphael Lota S Sadeed Rashid S Saurabh Asthana S Sharvari Bhide T Tasha Lea Y Yumiko Abe-Jones L Lauren I. R. Ehrlich (Department of Molecular Biosciences, The University of Texas at Austin) E Esther Melamed C Cole Maguire D Dennis Wylie J Justin F. Rousseau K Kerin C. Hurley J Janelle N. Geltman N Nadia Siles J Jacob E. Rogers P Pablo Guaman Tipan A Arun K. Boddapati G Greg K. Tharp K Kathryn L. Pellegrini B Brandi Johnson B Bernadine Panganiban C Christopher Huerta E Evan J. Anderson H Hady Samaha J Jonathan E. Sevransky L Laurel Bristow E Elizabeth Beagle D David Cowan S Sydney Hamilton T Thomas Hodder A Amer Bechnak A Andrew Cheng A Aneesh Mehta C Caroline R. Ciric C Christine Spainhour E Erin Carter E Erin M. Scherer J Jacob Usher K Kieffer Hellmeister L Laila Hussaini L Lauren Hewitt N Nina Mcnair S Sonia Wimalasena J Jordan P. Metcalf N Nelson I. Agudelo Higuita L Lauren A. Sinko J J. Leland Booth D Douglas A. Drevets B Brent R. Brown S Scott C. Brakenridge R Ricardo F. Ungaro B Brittany Roth Manning L Lyle Moldawer W William B. Messer C Catherine L. Hough S Sarah A. R. Siegel P Peter E. Sullivan Z Zhengchun Lu A Amanda E. Brunton M Matthew Strand Z Zoe L. Lyski F Felicity J. Coulter C Courtney Micheletti S Scott Presnell B Bernard Kohr T Tomasz Jancsyk A Azlann Arnett A Alison D. Augustine S Steven M. Holland L Lindsey B. Rosen S Serena Lee T Tatyana Vaysman J Jing Chen A Alvin T. Kho C Carly E. Milliren A Ana C. Chang K Kerry McEnaney C Caitlin Syphurs (Precision Vaccines Program, Boston Children’s Hospital) B Brenda Barton C Claudia Lentucci M Maimouna D. Murphy M Mehmet Saluvan T Tanzia Shaheen S Shanshan Liu M Marisa Albert A Arash Nemati Hayati R Robert Bryant J James Abraham M Mitchell Cooney M Meagan Karoly H Hanno Steen (Department of Pathology, Boston Children’s Hospital) P Patrick van Zalm B Benoit Fatou K Kinga K. Smolen (Harvard Medical School) A Arthur Viode S Simon van Haren M Meenakshi Jha D David Stevenson S Sanya Thomas B Boryana Petrova N Naama Kanarek A Ana Fernandez-Sesma V Viviana Simon H Harm van Bakel A Ana Silvia Gonzalez-Reiche J Jingjing Qi (Department of Pharmacology, Laboratory of Gene Regulation and Signal Transduction, University of California San Diego School of Medicine) B Brian Lee J Juan Manuel Carreño G Gagandeep Singh A Ariel Raskin J Johnstone Tcheou Z Zain Khalil A Adriana van de Guchte K Keith Farrugia Z Zenab Khan G Geoffrey Kelly K Komal Srivastava L Lily Q. Eaker M Maria C. Bermúdez-González L Lubbertus C. F. Mulder K Katherine F. Beach M Miti Saksena D Deena Altman E Erna Kojic L Levy A. Sominsky A Arman Azad D Dominika Bielak H Hisaaki Kawabata T Temima Yellin M Miriam Fried L Leeba Sullivan S Sara Morris G Giulio Kleiner D Daniel Stadlbauer J Jayeeta Dutta H Hui Xie M Manishkumar Patel K Kai Nie B Brian Monahan D David A. Hafler R Ruth R. Montgomery (Department of Internal Medicine, Yale School of Medicine) A Albert C. Shaw (Yale School of Medicine, New Haven, CT) J Jeremy P. Gygi D Dylan Duchen S Shrikant Pawar A Anna Konstorum E Ernie Chen (Department of Neurology, Yale School of Medicine) C Chris Cotsapas (Department of Neurology, Yale School of Medicine) X Xiaomei Wang (State Key Laboratory of Rare Earths) C Charles Dela Cruz A Akiko Iwasaki (Department of Immunobiology, Yale School of Medicine) S Subhasis Mohanty A Allison Nelson Y Yujiao Zhao S Shelli Farhadian H Hiromitsu Asashima O Omkar Chaudhary A Andreas Coppi J John Fournier M M. Catherine Muenker K Khadir Raddassi M Michael Rainone W William Ruff S Syim Salahuddin W Wade L. Shulz P Pavithra Vijayakumar H Haowei Wang E Esio Wunder H H. Patrick Young A Albert I. Ko G Gisela Gabernet D Denise Esserman (Yale School of Public Health) L Leying Guan A Anderson Brito J Jessica Rothman N Nathan D. Grubaugh K Kexin Wang (School of Engineering and Applied Sciences) L Leqi Xu H Holden Maecker B Bali Pulendran K Kari C. Nadeau Y Yael Rosenberg-Hasson (Department of Microbiology and Immunology, Stanford University School of Medicine) M Michael Leipold N Natalia Sigal A Angela Rogers A Andrea Fernandes M Monali Manohar E Evan Do I Iris Chang A Alexandra S. Lee C Catherine Blish H Henna Naz Din J Jonasel Roque L Linda N. Geng M Maja Artandi M Mark M. Davis (Institute of Immunity, Transplantation and Infection, Stanford University) N Neera Ahuja S Samuel S. Yang S Sharon Chinthrajah T Thomas Hagan T Tyson H. Holmes K Koji Abe L Lindsey R. Baden K Kevin Mendez (Harvard Medical School) J Jessica Lasky-Su (Harvard Medical School) A Alexandra Tong R Rebecca Rooks M Michael Desjardins A Amy C. Sherman S Stephen R. Walsh X Xhoi Mitre J Jessica Cauley X Xiaofang Li (Key Laboratory of Cluster Science of Ministry of Education, Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, 5 South Zhongguancun Street, Haidian District, Beijing 100081, China) B Bethany Evans C Christina Montesano J Jose Humberto Licona J Jonathan Krauss N Nicholas C. Issa J Jun Bai Park Chang N Natalie Izaguirre D David B. Corry F Farrah Kheradmand L Li-Zhen Song E Ebony Nelson M Monica Kraft C Chris Bime J Jarrod Mosier H Heidi Erickson R Ron Schunk H Hiroki Kimura M Michelle Conway D Dave Francisco A Allyson Molzahn C Connie Cathleen Wilson T Trina Hughes B Bianca Sierra J Jordan Oberhaus F Faheem W. Guirgis B Brittney Borresen M Matthew L. Anderson B Bjoern Peters R Randi Vita K Kerstin Westendorf S Scott J. Tebbutt C Casey P. Shannon R Rafick-Pierre Sekaly S Slim Fourati G Grace A. McComsey P Paul Harris S Scott Sieg G George Yendewa M Mary Consolo H Heather Tribout S Susan Pereira Ribeiro C Charles B. Cairns E Elias K. Haddad M Michele A. Kutzler M Mariana Bernui G Gina Cusimano J Jennifer Connors K Kyra Woloszczuk D David Joyner C Carolyn Edwards E Edward Lee E Edward Lin N Nataliya Melnyk D Debra L. Powell J James N. Kim I I. Michael Goonewardene B Brent Simmons C Cecilia M. Smith M Mark Martens B Brett Croen N Nicholas C. Semenza M Mathew R. Bell S Sara Furukawa R Renee McLin G George P. Tegos B Brandon Rogowski N Nathan Mege K Kristen Ulring P Pam Schearer J Judie Sheidy C Crystal Nagle J James A. Overton S Scott R. Hutton G Greg Michelotti K Kari Wong A Adeeb Rahman V Vicki Seyfert-Margolis R Ramin Salehi-Rad M Matthew C. Altman P Patrice M. Becker S Steven E. Bosinger (Department of Pathology & Laboratory Medicine, Emory University, Division of Microbiology and Immunology, Emory National Primate Research Center) W Walter Eckalbar A Annmarie Hoch N Naresh Doni Jayavelu S Seunghee Kim-Schulze M Meagan Jenkins S Steven H. Kleinstein (Department of Pathology, Yale School of Medicine) F Florian Krammer H Holden T. Maecker (Department of Microbiology and Immunology, Stanford University School of Medicine) A Al Ozonoff J Joann Diray-Arce (Harvard Medical School) A Albert Shaw L Lindsey Baden O Ofer Levy (Harvard Medical School) E Elaine F. Reed C Charles R. Langelier