Histone deacetylase SIRT6 regulates tryptophan catabolism and prevents metabolite imbalance associated with neurodegeneration

Shai Kaluski-Kopatch; Daniel Stein; Alfredo Garcia Venzor; Ana Margarida Ferreira Campos; Mélanie Planque; Bareket Goldstein; Estefanía De Allende-Becerra; Dmitrii Smirnov; Adam Zaretsky; Ekaterina Eremenko; Miguel Portillo; Monica Einav; Alena Bruce Krejci; Uri Abdu; Ekaterina Khrameeva; Daniel Gitler; Sarah-Maria Fendt; Debra Toiber

doi:10.1038/s41467-025-67021-y

Histone deacetylase SIRT6 regulates tryptophan catabolism and prevents metabolite imbalance associated with neurodegeneration

S Shai Kaluski-Kopatch D Daniel Stein (Department of Life Sciences, Ben-Gurion University of the Negev) A Alfredo Garcia Venzor A Ana Margarida Ferreira Campos M Mélanie Planque B Bareket Goldstein E Estefanía De Allende-Becerra D Dmitrii Smirnov A Adam Zaretsky E Ekaterina Eremenko M Miguel Portillo M Monica Einav A Alena Bruce Krejci U Uri Abdu E Ekaterina Khrameeva D Daniel Gitler S Sarah-Maria Fendt D Debra Toiber

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Article Details

Journal Nature Communications

Volume / Issue Vol. 17, Issue 1

Published December 04, 2025

DOI 10.1038/s41467-025-67021-y

ISSN 2041-1723

Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (18)

S

Shai Kaluski-Kopatch

D

Daniel Stein

Department of Life Sciences, Ben-Gurion University of the Negev

A

Alfredo Garcia Venzor

A

Ana Margarida Ferreira Campos

M

Mélanie Planque

B

Bareket Goldstein

E

Estefanía De Allende-Becerra

D

Dmitrii Smirnov

A

Adam Zaretsky

E

Ekaterina Eremenko

M

Miguel Portillo

M

Monica Einav

A

Alena Bruce Krejci

U

Uri Abdu

E

Ekaterina Khrameeva

D

Daniel Gitler

S

Sarah-Maria Fendt

D

Debra Toiber

Histone deacetylase SIRT6 regulates tryptophan catabolism and prevents metabolite imbalance associated with neurodegeneration

Article Details

Journal Info

Authors (18)

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