Hijacking innate immunity to enhance mRNA therapeutics by blocking IFN-P-body-XRN1 axis-mediated degradation

T Tinghong Zhang X Xing Peng J Jinling Qin B Binqiang Zhu S Shuaihua Zhang S Shijie Deng Z Zhimin Song Y Yulong Han (School of General Education and Foreign Languages, Anhui Institute of Information Technology 1 , Wuhu 241003,) H Hui Zheng (Department of Clinical Laboratory, Centre for Leading Medicine and Advanced Technologies of Institute of Health and Medicine, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China) J Jingjing Chen (School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences) Y Yun Zhang Y Yaofeng Wang J Jingyuan Zhang Y Yumin Zhou P Pixin Ran N Ningyi Shao B Bin Zhu Y Yunshen Chan S Shu Meng

Article Details

Volume / Issue Vol. 17, Issue 1
Published April 17, 2026
ISSN 2041-1723
Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (19)

T

Tinghong Zhang

X

Xing Peng

J

Jinling Qin

B

Binqiang Zhu

S

Shuaihua Zhang

S

Shijie Deng

Z

Zhimin Song

Y

Yulong Han

School of General Education and Foreign Languages, Anhui Institute of Information Technology 1 , Wuhu 241003,

H

Hui Zheng

Department of Clinical Laboratory, Centre for Leading Medicine and Advanced Technologies of Institute of Health and Medicine, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China

J

Jingjing Chen

School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences

Y

Yun Zhang

Y

Yaofeng Wang

J

Jingyuan Zhang

Y

Yumin Zhou

P

Pixin Ran

N

Ningyi Shao

B

Bin Zhu

Y

Yunshen Chan

S

Shu Meng