Highly efficient and long-acting split-and-mix proteolysis targeting chimera based on self-assembled polylactic acid

M Mei-miao Zhan H Hailing Chen M Meiling He (School of Biology and Biological Engineering, South China University of Technology) C Chunli Song Z Zijun Jiao (State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology) N Na Liu Z Zhihong Liu Z Zhanfeng Hou Y Ying Chen Z Zhibo Song (School of Advanced Materials) Y Yun Xing (MOE Key Laboratory of Resources and Environmental System Optimization, College of Environmental Science and Engineering) Z Zigang Li (State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology) F Feng Yin (State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology)

Article Details

Volume / Issue Vol. 16, Issue 1
Published November 26, 2025
ISSN 2041-1723
Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (13)

M

Mei-miao Zhan

H

Hailing Chen

M

Meiling He

School of Biology and Biological Engineering, South China University of Technology

C

Chunli Song

Z

Zijun Jiao

State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology

N

Na Liu

Z

Zhihong Liu

Z

Zhanfeng Hou

Y

Ying Chen

Z

Zhibo Song

School of Advanced Materials

Y

Yun Xing

MOE Key Laboratory of Resources and Environmental System Optimization, College of Environmental Science and Engineering

Z

Zigang Li

State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology

F

Feng Yin

State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology