HIF-2α induces aggravated intervertebral disc degeneration by activating the IL-6/hepcidin-FPN1 axis and promoting ferroptosis in nucleus pulposus cells

L Li-Ming He J Jian Gao Q Qiang Chang Z Zhuo Ma X Xiao-Ming Guan W Wen-Bo Liu (Hubei Research Center of Fundamental Science-Chemistry, Engineering Research Center of Organosilicon Compounds & Materials (Ministry of Education), Hubei Key Lab on Organic and Polymeric Optoelectronic Materials, and College of Chemistry and Molecular Sciences) Z Zhen-Wu Gao L Lei-Min Xi Y Yue Zhou H Hao-Yu Feng

Article Details

Volume / Issue Vol. 1, Issue 1
Published June 17, 2026
ISSN 2045-2322
Publisher Nature Portfolio

Journal Info

Scientific Reports

Nature Portfolio

ISSN: 2045-2322 Open Access Life Sciences

Authors (10)

L

Li-Ming He

J

Jian Gao

Q

Qiang Chang

Z

Zhuo Ma

X

Xiao-Ming Guan

W

Wen-Bo Liu

Hubei Research Center of Fundamental Science-Chemistry, Engineering Research Center of Organosilicon Compounds & Materials (Ministry of Education), Hubei Key Lab on Organic and Polymeric Optoelectronic Materials, and College of Chemistry and Molecular Sciences

Z

Zhen-Wu Gao

L

Lei-Min Xi

Y

Yue Zhou

H

Hao-Yu Feng