HEPATOPROTECTIVE POTENTIAL OF VARIOUS EXTRACTS OF COCCINAINDICA, SIDACORDATA, MEDICAGO SATIVA AND WEDELIATRILOBATA

Abstract

Background - The liver is a crucial organ that is important for the body's removal of xenobiotics. The pharmaceutical business, as well as healthcare practitioners, are challenged by diseases that affect the liver. Botanical medications are frequently employed since the standard therapy for liver problems is linked to a wide variety of negative effects. Objective - To evaluate the hepatoprotective activity of the various extracts of Coccinaindica, Sidacordata, Medicago sativa and . Wedeliatrilobata leaves in mice. Methods– The chosen plant parts has been grounded to the fine powder form and this powder is then sieved with a particular number of sieve that is number 40 so as to obtain a uniform powder. Further to this this powder is under gone with WHO guideline.It was found that the specified limits were within all the measured parameters.  After physicochemical characterization, all of the plant components were extracted using Pet ether., Chloroform, Ethanol and Aqueous.The evaluation was designed to understand the pharmacological activity at various dose levels of each plant substance, in order to select the appropriate doses. Results – Extremely reactive free radical CCl3 specifically targets polyunsaturated endoplasmic reticulum fatty acids in hepatocytes and thus causes over production of Aspartate aminotransferase,  Alkaline phosphatase and alanine amino transferase and serum bilirubin.serum enzyme levels of when CCl4 was used to cause liver toxicity increased significantly. of Aspartate aminotransferase, Alkaline phosphatase and alanine amino transferase,Serum bilirubin (T and D) and decrease the levels of total protein. The biochemical evaluation of the liver enzymes showed a potential hepatoprotective effect of Alcoholic (Ethanolic) extract of Cocciniaindica (CIEE); Aq. extract of Sidacordata(SCAE), Alcoholic (Ethanolic) extract of Wedeliatrilobata(WTEE) and ethanolic extract of Medicago sativa(MSEE) in the experimental rat models. The selected medicinal plants are widely employed in various liver disorders in traditional systems of medicine. The present pharmacological evaluation will provide scientific data about the rationale behind their use.