HEPATOPROTECTIVE EVALUATION OF ZIZIPHUS MAURITIANA BARK EXTRACT ON EXPERIMENTAL ANIMALS

Abstract

The present investigation entitled “Hepatoprotective Evaluation of Ziziphus Mauritiana Bark Extract on Experimental Animals has been carried out and presented in the thesis. The present investigation is concerned with the widely distributed indigenous plants Ziziphus Mauritiana. From the survey of literature of this plant, it is observed that this plant is well known. In order to do a systematic study on a lead molecule discovery and optimization, we have gone in for a treatment of a set of ailments by diverse plants species from different family. Ziziphus Mauritiana belongs to the family of Rhammaceae was reported to possess anti-inflammatory, anti-covulsant, skin infection, antioxidant activity. It is a medium to large trees, 12 m in hight, bark dark brown, found in villeges forest on wastelands throughout india. The work involves extraction, GC-MS, pharmacological screening of the extracts, isolation and characterization of constituents by using modern analytical techniques. Keeping in view of the various medicinal uses of the plant mentioned in the literature pharmacological evaluation was carried out to substantiate folklore claim. Toxicity studied result revealed that both EE an aqueous extract on oral route was safe to administer at high dose of 2000 mg/kg