Harnessing BET-Bromodomain Assisted Nuclear Import for Targeted Subcellular Localization and Enhanced Efficacy of Antisense Oligonucleotides

D Disha Kashyap (Department of Chemistry, University of Oxford, Mansfield Road, Oxford OX1 3TA, U.K.) M Martina Cadeddu (MRC Nucleic Acid Therapy Accelerator, Research Complex at Harwell, Harwell Campus, Oxford OX11 0FA, U.K.) P Peter L. Oliver (MRC Nucleic Acid Therapy Accelerator, Research Complex at Harwell, Harwell Campus, Oxford OX11 0FA, U.K.) T Thomas A. Milne (MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine) M Michael J. Booth (Department of Chemistry, University of Oxford, Mansfield Road, Oxford OX1 3TA, U.K.)

Article Details

Volume / Issue Vol. 147, Issue 32
Published August 13, 2025
Pages 29478-29488
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (5)

D

Disha Kashyap

Department of Chemistry, University of Oxford, Mansfield Road, Oxford OX1 3TA, U.K.

M

Martina Cadeddu

MRC Nucleic Acid Therapy Accelerator, Research Complex at Harwell, Harwell Campus, Oxford OX11 0FA, U.K.

P

Peter L. Oliver

MRC Nucleic Acid Therapy Accelerator, Research Complex at Harwell, Harwell Campus, Oxford OX11 0FA, U.K.

T

Thomas A. Milne

MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine

M

Michael J. Booth

Department of Chemistry, University of Oxford, Mansfield Road, Oxford OX1 3TA, U.K.