Glycoengineered Host-Guest Nanoparticles Potentiate Alzheimer’s Disease Therapy via Lesion-Specific Modulation of Tau Pathology

Y Yi Lai (State Key Laboratory of Chemical Biology and Center of Pharmaceutics, Shanghai Institute of Materia Medica) J Jiaxing Pan (State Key Laboratory of Chemical Biology and Center of Pharmaceutics, Shanghai Institute of Materia Medica) Y Yuejiao Gu (Department of Medicinal Chemistry, Shanghai Institute of Materia Medica) C Chuan Zhou (Department of Medicinal Chemistry, Shanghai Institute of Materia Medica) W Wenfang Yang (State Key Laboratory of Chemical Biology and Center of Pharmaceutics, Shanghai Institute of Materia Medica) Q Qian Zhao (Zhejiang University , , ,) Z Zifan Zhu (School of Chemistry and Molecular Engineering) Y Yanhong Duan (Key Laboratory of Brain Functional Genomics, Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, School of Life Sciences) L Li Lei (Engineering Research Center for Molecular Medicine, School of Basic Medical Science) Y Ying Fu H Haiyan Zhang (State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica) B Boyan Fang (Parkinson Medical Center, Beijing Rehabilitation Hospital) T Tianfeng Xu (Department of Medicinal Chemistry, Shanghai Institute of Materia Medica) Z Zhiai Xu (School of Chemistry and Molecular Engineering) H Haijun Yu (State Key Laboratory of Chemical Biology and Center of Pharmaceutics, Shanghai Institute of Materia Medica)

Article Details

Volume / Issue Vol. 148, Issue 23
Published June 17, 2026
Pages 24287-24305
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (15)

Y

Yi Lai

State Key Laboratory of Chemical Biology and Center of Pharmaceutics, Shanghai Institute of Materia Medica

J

Jiaxing Pan

State Key Laboratory of Chemical Biology and Center of Pharmaceutics, Shanghai Institute of Materia Medica

Y

Yuejiao Gu

Department of Medicinal Chemistry, Shanghai Institute of Materia Medica

C

Chuan Zhou

Department of Medicinal Chemistry, Shanghai Institute of Materia Medica

W

Wenfang Yang

State Key Laboratory of Chemical Biology and Center of Pharmaceutics, Shanghai Institute of Materia Medica

Q

Qian Zhao

Zhejiang University , , ,

Z

Zifan Zhu

School of Chemistry and Molecular Engineering

Y

Yanhong Duan

Key Laboratory of Brain Functional Genomics, Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, School of Life Sciences

L

Li Lei

Engineering Research Center for Molecular Medicine, School of Basic Medical Science

Y

Ying Fu

H

Haiyan Zhang

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica

B

Boyan Fang

Parkinson Medical Center, Beijing Rehabilitation Hospital

T

Tianfeng Xu

Department of Medicinal Chemistry, Shanghai Institute of Materia Medica

Z

Zhiai Xu

School of Chemistry and Molecular Engineering

H

Haijun Yu

State Key Laboratory of Chemical Biology and Center of Pharmaceutics, Shanghai Institute of Materia Medica