Genome-wide in vivo CRISPR screens identify GATOR1 complex as a tumor suppressor in Myc-driven lymphoma

Margaret A. Potts; Shinsuke Mizutani; Yexuan Deng; Srimayee Vaidyanathan; Keziah E. Ting; Göknur Giner; Shruti Sridhar; Girija Shenoy; Yang Liao; Sarah T. Diepstraten; Andrew J. Kueh; Martin Pal; Geraldine Healey; Lin Tai; Zilu Wang; Christina König; Deeksha Kaloni; Lauren Whelan; Michael J. G. Milevskiy; Hannah D. Coughlan; Giovanna Pomilio; Andrew H. Wei; Jane E. Visvader; Anthony T. Papenfuss; Stephen Wilcox; Anand D. Jeyasekharan; Wei Shi; Emily J. Lelliott; Gemma L. Kelly; Kristin K. Brown; Andreas Strasser; Marco J. Herold

doi:10.1038/s41467-025-62615-y

Genome-wide in vivo CRISPR screens identify GATOR1 complex as a tumor suppressor in Myc-driven lymphoma

M Margaret A. Potts S Shinsuke Mizutani Y Yexuan Deng S Srimayee Vaidyanathan K Keziah E. Ting G Göknur Giner S Shruti Sridhar G Girija Shenoy Y Yang Liao (Center for Water and Ecology, State Key Laboratory of Regional Environment and Sustainability, School of Environment) S Sarah T. Diepstraten A Andrew J. Kueh M Martin Pal G Geraldine Healey L Lin Tai Z Zilu Wang C Christina König D Deeksha Kaloni L Lauren Whelan M Michael J. G. Milevskiy H Hannah D. Coughlan G Giovanna Pomilio A Andrew H. Wei J Jane E. Visvader A Anthony T. Papenfuss S Stephen Wilcox A Anand D. Jeyasekharan W Wei Shi E Emily J. Lelliott G Gemma L. Kelly K Kristin K. Brown A Andreas Strasser M Marco J. Herold

Download PDF View Original

APA MLA Chicago BibTeX RIS

Article Details

Journal Nature Communications

Volume / Issue Vol. 16, Issue 1

Published August 21, 2025

DOI 10.1038/s41467-025-62615-y

ISSN 2041-1723

Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (32)

M

Margaret A. Potts

S

Shinsuke Mizutani

Y

Yexuan Deng

S

Srimayee Vaidyanathan

K

Keziah E. Ting

G

Göknur Giner

S

Shruti Sridhar

G

Girija Shenoy

Y

Yang Liao

Center for Water and Ecology, State Key Laboratory of Regional Environment and Sustainability, School of Environment

S

Sarah T. Diepstraten

A

Andrew J. Kueh

M

Martin Pal

G

Geraldine Healey

L

Lin Tai

Z

Zilu Wang

C

Christina König

D

Deeksha Kaloni

L

Lauren Whelan

M

Michael J. G. Milevskiy

H

Hannah D. Coughlan

G

Giovanna Pomilio

A

Andrew H. Wei

J

Jane E. Visvader

A

Anthony T. Papenfuss

S

Stephen Wilcox

A

Anand D. Jeyasekharan

W

Wei Shi

E

Emily J. Lelliott

G

Gemma L. Kelly

K

Kristin K. Brown

A

Andreas Strasser

M

Marco J. Herold

Genome-wide in vivo CRISPR screens identify GATOR1 complex as a tumor suppressor in Myc-driven lymphoma

Article Details

Journal Info

Authors (32)

Related Articles from this Journal

Synthesis of adaptive 15N-nitrosyl-Co7 nanocluster for electrocatalytic C–H functionalization

Pan-Ebolavirus nanoparticle vaccine provides protection in rodents from lethal infection by Zaire and Sudan viruses

Multi-population GWAS meta-analysis identifies bladder cancer susceptibility loci and highlights genetic regulation of smoking-related risk

Genome-wide annotation of human multi-nucleotide variants reveals widespread functional differences from single nucleotide variants

Allele-specific chromatin architecture shapes imprinted domains and coordinates a distal enhancer and antisense transcription at the mouse Mest-Copg2 domain