Genetically Predicted IL-18 Inhibition and Risk of Cardiovascular Events: A Mendelian Randomization Study

Stephen O. Brennan; Peter J. Kelly; Sarah Gorey; Pádraig Synnott; Dipender Gill; Martin Dichgans; Marios K. Georgakis; Marie-Joe Dib; Eloi Gagnon; Niall Mahon; Gavin J. Blake; Christina Jern; Hugh S. Markus; William Whiteley; John J. McCabe

doi:10.1161/circulationaha.124.072238

Genetically Predicted IL-18 Inhibition and Risk of Cardiovascular Events: A Mendelian Randomization Study

S Stephen O. Brennan (Departments of Neurology (S.O.B., P.J.K.), Mater Misericordiae University Hospital, Dublin, Ireland.) P Peter J. Kelly (Mater Misericordiae University Hospital, Dublin, Ireland (P.J.K.).) S Sarah Gorey (Geriatric Medicine Fellowship Program, Harvard Medical School, Boston) P Pádraig Synnott (Health Research Board, Stroke Clinical Trials Network Ireland, Dublin, Ireland (P.J.K., S.G., P.S., J.J.M.).) D Dipender Gill M Martin Dichgans M Marios K. Georgakis (Institute for Stroke and Dementia Research, University Hospital, LMU Munich, Germany (M.D., M.K.G.).) M Marie-Joe Dib (Cardiovascular Division, Perelman School for Advanced Medicine, University of Pennsylvania, Philadelphia (M.-J.D.).) E Eloi Gagnon (Centre de Recherche de l’Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Canada (E.G.).) N Niall Mahon (Stroke Service, and Department of Cardiology (N.M., G.J.B.), Mater Misericordiae University Hospital, Dublin, Ireland.) G Gavin J. Blake (Stroke Service, and Department of Cardiology (N.M., G.J.B.), Mater Misericordiae University Hospital, Dublin, Ireland.) C Christina Jern H Hugh S. Markus W William Whiteley J John J. McCabe (Geriatric Medicine (J.J.M.), Mater Misericordiae University Hospital, Dublin, Ireland.)

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Article Details

Journal Circulation

Volume / Issue Vol. 151, Issue 5

Published February 04, 2025

Pages 334-336

DOI 10.1161/circulationaha.124.072238

ISSN 0009-7322

Publisher Lippincott Williams & Wilkins

Journal Info

Circulation

Lippincott Williams & Wilkins

ISSN: 0009-7322 Health Sciences

Authors (15)

S

Stephen O. Brennan

Departments of Neurology (S.O.B., P.J.K.), Mater Misericordiae University Hospital, Dublin, Ireland.

P

Peter J. Kelly

Mater Misericordiae University Hospital, Dublin, Ireland (P.J.K.).

S

Sarah Gorey

Geriatric Medicine Fellowship Program, Harvard Medical School, Boston

P

Pádraig Synnott

Health Research Board, Stroke Clinical Trials Network Ireland, Dublin, Ireland (P.J.K., S.G., P.S., J.J.M.).

D

Dipender Gill

M

Martin Dichgans

M

Marios K. Georgakis

Institute for Stroke and Dementia Research, University Hospital, LMU Munich, Germany (M.D., M.K.G.).

M

Marie-Joe Dib

Cardiovascular Division, Perelman School for Advanced Medicine, University of Pennsylvania, Philadelphia (M.-J.D.).

E

Eloi Gagnon

Centre de Recherche de l’Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Canada (E.G.).

N

Niall Mahon

Stroke Service, and Department of Cardiology (N.M., G.J.B.), Mater Misericordiae University Hospital, Dublin, Ireland.

G

Gavin J. Blake

Stroke Service, and Department of Cardiology (N.M., G.J.B.), Mater Misericordiae University Hospital, Dublin, Ireland.

C

Christina Jern

H

Hugh S. Markus

W

William Whiteley

J

John J. McCabe

Geriatric Medicine (J.J.M.), Mater Misericordiae University Hospital, Dublin, Ireland.

Genetically Predicted IL-18 Inhibition and Risk of Cardiovascular Events: A Mendelian Randomization Study

Article Details

Journal Info

Authors (15)

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