Genetic Code Expansion in Probiotics Enables the Secretion of Covalent Protein Drugs in Mice

K Kaiyi Wang (State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica) Y Yumeng Wu J Jiamin Shang (State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica) L Lingxin Bu (State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica) D Da Hu (State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica) H Honglin He (State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica) R Ruixuan Wang J Junyi Mao (State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica) Y Yao Yan (State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica) J Jun Guan (State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica) R Rui Wang H Huixin Luo (State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica)

Article Details

Volume / Issue Vol. 148, Issue 1
Published January 14, 2026
Pages 1397-1405
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (12)

K

Kaiyi Wang

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica

Y

Yumeng Wu

J

Jiamin Shang

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica

L

Lingxin Bu

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica

D

Da Hu

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica

H

Honglin He

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica

R

Ruixuan Wang

J

Junyi Mao

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica

Y

Yao Yan

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica

J

Jun Guan

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica

R

Rui Wang

H

Huixin Luo

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica