Galvanic Cell Bipolar Microneedle Patches for Reversing Photoaging Wrinkles
Abstract
AbstractExcessive exposure to ultraviolet (UV) radiation is a major factor in the development of skin photoaging wrinkles. While current treatments can slow the progression of photoaging, it is very difficult to achieve complete reversal. This study introduces galvanic cell microneedle (GCMN) patches with magnesium‐containing bipolar electrodes. These patches operate through a galvanic cell mechanism, generating microcurrents and releasing hydrogen gas and magnesium ions via a redox reaction. The combination of hydrogen's antioxidant and anti‐inflammatory properties, microcurrent‐induced stimulation of cell migration, and magnesium's promotion of angiogenesis and macrophage M2 anti‐inflammatory polarization synergistically works to reverse photoaging wrinkles and rejuvenate the skin. Furthermore, this work examines how GCMNs may influence the transforming growth factor‐β/Smad (TGF‐β/Smad) pathway. This approach shows promise for advancing research and development in the field of medical cosmetology.
Article Details
Authors (9)
Xinyuan Lin
Qing Jia
Xuanyi Lin
Key Laboratory of Dental Maxillofacial Reconstruction and Biological Intelligence Manufacturing, Gansu Province, School of Stomatology Lanzhou University Lanzhou 730000 P. R. China
Jiakai Shi
Key Laboratory of Dental Maxillofacial Reconstruction and Biological Intelligence Manufacturing School of Stomatology Lanzhou University Lanzhou Gansu Province P. R. China
Wanru Gong
Kuangyu Shen
Polymer Program, Institute of Materials Science and Department of Chemical & Biomolecular Engineering University of Connecticut Storrs Connecticut 06269 USA
Bin Liu
Luyi Sun
Polymer Program, Institute of Materials Science and Department of Chemical and Biomolecular Engineering
Zengjie Fan
Jiangsu Key Laboratory of Materials and Technologies for Energy Storage College of Materials Science and Technology Nanjing University of Aeronautics and Astronautics Nanjing 211106 China