Frustration in the protein-protein interface plays a central role in the cooperativity of PROTAC ternary complexes

N Ning Ma S Supriyo Bhattacharya S Sanychen Muk Z Zuzana Jandova P Philipp S. Schmalhorst S Soumadwip Ghosh K Keith Le E Emelyne Diers (Division of Biological Chemistry and Drug Discovery, School of Life Sciences, James Black Centre) N Nicole Trainor (Division of Biological Chemistry and Drug Discovery, School of Life Sciences, James Black Centre) W William Farnaby (Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, 1 James Lindsay Place, DD1 5JJ Dundee, Scotland, U.K.) M Michael J. Roy C Christiane Kofink P Peter Greb H Harald Weinstabl A Alessio Ciulli (Centre for Targeted Protein Degradation, School of Life Sciences) G Gerd Bader K Kyra Sankar A Andreas Bergner N Nagarajan Vaidehi