From data to diagnosis: An innovative approach to epilepsy prediction with CGTNet incorporating spatio-temporal features

D Dianli Wang E Enping Li Y Yang Wang Z Zhiyang Liu A Aixia Sun W Wei Wei X Xuning Zhang C Cheng Peng (College of Chemistry and Molecular Engineering) F Fengtao Wei

Abstract

Epilepsy affects around 50 million people globally, causing significant burdens. While many methods predict seizures, current models struggle with handling spatiotemporal features and balancing accuracy with computational efficiency.This paper introduces a novel deep learning architecture called CGTNet, which is composed of a multi-scale convolutional network, gated recurrent units (GRUs), and Sparse Transformers. It is specifically designed for analyzing elec-troencephalogram (EEG) data to predict epileptic seizures. CGTNet enhances the ability to extract spatiotemporal features from EEG signals, demonstrating its exceptional performance in seizure prediction through rigorous evaluation on the renowned CHB-MIT and SWEC-ETHZ EEG datasets. The model achieved an accuracy of 98.89%, sensitivity of 98.52%, specificity of 98.53%, an AUROC value of 0.97, and an MCC value of 0.975 on these datasets. These results not only highlight the technical innovations of CGTNet but also validate the immense potential of deep learning in processing medical signals. Our research provides an effective new tool for early detection and continuous monitoring of epilepsy, laying the foundation for advancing healthcare with artificial intelligence technology.

Article Details

Journal PLoS ONE
Volume / Issue Vol. 20, Issue 12
Published December 02, 2025
Pages e0337007
ISSN 1932-6203
Publisher Public Library of Science

Journal Info

PLoS ONE

Public Library of Science

ISSN: 1932-6203 Open Access Health Sciences

Authors (9)

D

Dianli Wang

E

Enping Li

Y

Yang Wang

Z

Zhiyang Liu

A

Aixia Sun

W

Wei Wei

X

Xuning Zhang

C

Cheng Peng

College of Chemistry and Molecular Engineering

F

Fengtao Wei