FORMULATION AND OPTIMIZATION OF CHITOSAN MICROSPHERE OF SALBUTAMOL SULPHATE ON BASIS OF AMOUNT OF CROSS LINKING AGENT AND ON BASIS OF CROSS LINKING TIME FOR THE TREATMENT OF NOCTURNAL ASTHMA

Abstract

The process that occur periodically in an organism in conjunction with and often in response to periodic changes in environmental condition Biological rhythm within a single day is termed as circadian rhythm. Chronobiology is the technical study of biologic rhythms and their fundamental mechanisms4. The term "Chrono" pertains to time and "Biology" is the science of life, thus, chronobiology concerns with the observation of every metabolic event goes through rhythmic changes in time that can be measured from seconds to seasons. Chronotherapeutics is the synchronization of medication levels in time with reference to need, taking into account biologic rhythms in the pathophysiology of medical conditions, and/or rhythm dependencies in patient tolerance for given chemical interventions. In this study  design and characterize an oral, pulsatile drug delivery system of Salbutamol Sulphate intended to approximate the chronobiology of asthma, proposed for colonic targeting. It is a chronopharmaceutical approach for the better treatment of nocturnal asthma. The ultimate aim of this proposal is to design a new Chronotherapeutics system for salbutamol sulphate with high potential benefits in treating nocturnal asthma. Based on the concept that at the pH of colon various polymers release the drug due to their solubility at specified pH, a pH dependent pulsatile drug delivery system was designed.