Fluorinated Ionizable Lipids for Efficient Spleen-Targeted mRNA Delivery in Cancer Immunotherapy

Y Yanhao Zhang (Department of Pharmacy, The First Affiliated Hospital of the University of Science and Technology of China, and State Key Laboratory of Precision and Intelligent Chemistry) B Bing Shao (Department of Chemistry) K Kai Jiang (Department of Pharmacy, The First Affiliated Hospital of the University of Science and Technology of China, and State Key Laboratory of Precision and Intelligent Chemistry) J Jie Cen (State Key Laboratory of Precision and Intelligent Chemistry, Department of Polymer Science and Engineering) Y Yang Liu J Jiajia Tan (State Key Laboratory of Precision and Intelligent Chemistry, Department of Polymer Science and Engineering, School of Chemistry and Materials Science) L Lin Zhang K Keyu Li (Department of Pharmacy, The First Affiliated Hospital of the University of Science and Technology of China, and State Key Laboratory of Precision and Intelligent Chemistry) C Chengying You (Department of Pharmacy, The First Affiliated Hospital of the University of Science and Technology of China, and State Key Laboratory of Precision and Intelligent Chemistry) Z Zhihua He (State Key Laboratory of Precision and Intelligent Chemistry, Department of Polymer Science and Engineering) G Guoying Zhang (State Key Laboratory of Precision and Intelligent Chemistry, Department of Polymer Science and Engineering, School of Chemistry and Materials Science) M Minglong Chen (State Key Laboratory of Precision and Intelligent Chemistry, Department of Polymer Science and Engineering) J Jinming Hu S Shiyong Liu (State Key Laboratory of Precision and Intelligent Chemistry, Department of Polymer Science and Engineering, School of Chemistry and Materials Science)

Article Details

Volume / Issue Vol. 147, Issue 45
Published November 12, 2025
Pages 41756-41767
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (14)

Y

Yanhao Zhang

Department of Pharmacy, The First Affiliated Hospital of the University of Science and Technology of China, and State Key Laboratory of Precision and Intelligent Chemistry

B

Bing Shao

Department of Chemistry

K

Kai Jiang

Department of Pharmacy, The First Affiliated Hospital of the University of Science and Technology of China, and State Key Laboratory of Precision and Intelligent Chemistry

J

Jie Cen

State Key Laboratory of Precision and Intelligent Chemistry, Department of Polymer Science and Engineering

Y

Yang Liu

J

Jiajia Tan

State Key Laboratory of Precision and Intelligent Chemistry, Department of Polymer Science and Engineering, School of Chemistry and Materials Science

L

Lin Zhang

K

Keyu Li

Department of Pharmacy, The First Affiliated Hospital of the University of Science and Technology of China, and State Key Laboratory of Precision and Intelligent Chemistry

C

Chengying You

Department of Pharmacy, The First Affiliated Hospital of the University of Science and Technology of China, and State Key Laboratory of Precision and Intelligent Chemistry

Z

Zhihua He

State Key Laboratory of Precision and Intelligent Chemistry, Department of Polymer Science and Engineering

G

Guoying Zhang

State Key Laboratory of Precision and Intelligent Chemistry, Department of Polymer Science and Engineering, School of Chemistry and Materials Science

M

Minglong Chen

State Key Laboratory of Precision and Intelligent Chemistry, Department of Polymer Science and Engineering

J

Jinming Hu

S

Shiyong Liu

State Key Laboratory of Precision and Intelligent Chemistry, Department of Polymer Science and Engineering, School of Chemistry and Materials Science