FLAG-IDA plus venetoclax for children, adolescents, and young adults with newly diagnosed AML
Abstract
Abstract FLAG-IDA (fludarabine, cytarabine, granulocyte colony-stimulating factor, idarubicin) with venetoclax shows promise as frontline pediatric acute myeloid leukemia therapy. In 12 patients treated at MD Anderson, most achieved remission with good early survival outcomes, and many proceeded to transplant. Common toxicities included cytopenias, comparable to previous regimens.
Article Details
Authors (23)
Reeja Raj
1Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX
Samanta Catueno
1Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX
Amber Gibson
1Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX
David McCall
1Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX
Miriam B. Garcia
1Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX
César Nunez
1Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX
Michael Roth
MD Anderson Cancer Center, Houston, Texas, United States
Koji Sasaki
1The University of Texas MD Anderson Cancer Center, Houston, TX
Priti Tewari
3Division of Pediatrics, Pediatric Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX
Ghayas C. Issa
Aziz Farhat
2Division of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
Jeremy Connors
3Division of Pediatrics, Pediatric Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX
Irtiza Sheikh
3Division of Pediatrics, Pediatric Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX
Yuki Nishida
Joanna S. Yi
4Division of Pediatrics, Baylor College of Medicine, Houston, TX
Alexandra M. Stevens
Alex Bataller
2Division of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
Kapil Bhalla
2Division of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
Demetrios Petropoulos
3Division of Pediatrics, Pediatric Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX
Naval Daver
1The University of Texas MD Anderson Cancer Center, Houston, TX
Tapan Kadia
2Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
Branko Cuglievan
Courtney D. DiNardo
Department of Leukemia The University of Texas MD Anderson Cancer Center Houston Texas USA