First-Line Zongertinib in Advanced <i>HER2</i> -Mutant Non–Small-Cell Lung Cancer

J John V. Heymach N Noboru Yamamoto (Department of Experimental Therapeutics, National Cancer Center Hospital, Tokyo) N Nicolas Girard (Institut Curie, Institut du Thorax Curie-Montsouris, Paris) G Gerrina Ruiter (Department of Clinical Pharmacology, Netherlands Cancer Institute, Amsterdam) E Egbert F. Smit D David Planchard E Ernest Nadal (Thoracic Tumors Unit, Medical Oncology, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute, L’Hospitalet de Llobregat, Barcelona) Y Yi-Long Wu (Guangdong Lung Cancer Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China) J Jon Zugazagoitia (Department of Medical Oncology, 12 de Octubre Hospital, Madrid) H Hai-Yan Tu (Guangdong Lung Cancer Institute, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China) C Christina S. Baik (Thoracic, Head and Neck Medical Oncology, Fred Hutchinson Cancer Center, University of Washington, Seattle) K Kiyotaka Yoh (Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan) R Ross A. Soo (Department of Hematology–Oncology, National University Cancer Institute, Singapore) Y Yanqiu Zhao (Department of Medical Oncology, Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, China) J Joshua K. Sabari (Division of Medical Oncology, Perlmutter Cancer Center, New York University Langone Health, New York) M Martin Wermke (National Center for Tumor Diseases–University Cancer Center Early Clinical Trial Unit, Technische Universität Dresden, Dresden, Germany) M Matthias Scheffler M Myung-Ju Ahn (Department of Hematology and Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea) K Kristie Fernamberg (Boehringer Ingelheim Pharmaceuticals, Ridgefield, CT) L Lukas Schroeter (Boehringer Ingelheim Pharma, Biberach an der Riss, Germany) B Behbood Sadrolhefazi (Boehringer Ingelheim Pharmaceuticals, Ridgefield, CT) C Claus Thamer (Boehringer Ingelheim Pharma, Biberach an der Riss, Germany) S Sabina Eigenbrod-Giese (Boehringer Ingelheim International, Ingelheim am Rhein, Germany) S Sanjay Popat

Article Details

Volume / Issue Vol. 394, Issue 17
Published April 30, 2026
Pages 1675-1684
ISSN 0028-4793
Publisher Massachusetts Medical Society

Journal Info

New England Journal of Medicine

Massachusetts Medical Society

ISSN: 0028-4793 Social Sciences

Authors (24)

J

John V. Heymach

N

Noboru Yamamoto

Department of Experimental Therapeutics, National Cancer Center Hospital, Tokyo

N

Nicolas Girard

Institut Curie, Institut du Thorax Curie-Montsouris, Paris

G

Gerrina Ruiter

Department of Clinical Pharmacology, Netherlands Cancer Institute, Amsterdam

E

Egbert F. Smit

D

David Planchard

E

Ernest Nadal

Thoracic Tumors Unit, Medical Oncology, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute, L’Hospitalet de Llobregat, Barcelona

Y

Yi-Long Wu

Guangdong Lung Cancer Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China

J

Jon Zugazagoitia

Department of Medical Oncology, 12 de Octubre Hospital, Madrid

H

Hai-Yan Tu

Guangdong Lung Cancer Institute, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China

C

Christina S. Baik

Thoracic, Head and Neck Medical Oncology, Fred Hutchinson Cancer Center, University of Washington, Seattle

K

Kiyotaka Yoh

Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan

R

Ross A. Soo

Department of Hematology–Oncology, National University Cancer Institute, Singapore

Y

Yanqiu Zhao

Department of Medical Oncology, Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, China

J

Joshua K. Sabari

Division of Medical Oncology, Perlmutter Cancer Center, New York University Langone Health, New York

M

Martin Wermke

National Center for Tumor Diseases–University Cancer Center Early Clinical Trial Unit, Technische Universität Dresden, Dresden, Germany

M

Matthias Scheffler

M

Myung-Ju Ahn

Department of Hematology and Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea

K

Kristie Fernamberg

Boehringer Ingelheim Pharmaceuticals, Ridgefield, CT

L

Lukas Schroeter

Boehringer Ingelheim Pharma, Biberach an der Riss, Germany

B

Behbood Sadrolhefazi

Boehringer Ingelheim Pharmaceuticals, Ridgefield, CT

C

Claus Thamer

Boehringer Ingelheim Pharma, Biberach an der Riss, Germany

S

Sabina Eigenbrod-Giese

Boehringer Ingelheim International, Ingelheim am Rhein, Germany

S

Sanjay Popat