FAP-Synergistic Organ-Targeted mRNA-LNP for Overcoming Delivery Barriers in Hepatic and Pulmonary Fibrosis

C Chenlong Wei (State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences) X Xinzhu Shan (State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences) Y Yuxuan Huang (State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences) B Bin Ma (State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences) Z Zhiqiang Zhao (Department of Materials Science and Engineering) Y Yian Fang (State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences) C Chengrui Bai (State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences) Z Zihan Zhang P Peng Zhao H Huijuan Zhang (Department of Oncology The Affiliated Yantai Yuhuangding Hospital of Qingdao University Medical College Yantai China) Y Yu Hou (State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences) T Tianjiao Ji (CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology) Z Zhongtang Li (State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences) S Song Song (State Key Laboratory of Chemical Engineering and Low-Carbon Technology, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Haihe Laboratory of Sustainable Chemical Transformations, Tianjin Key Laboratory of Applied Catalysis Science and Engineering, School of Chemical Engineering & Technology) F Fei Xie (State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China) L Lei Miao (State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences)

Article Details

Volume / Issue Vol. 148, Issue 9
Published March 11, 2026
Pages 9309-9327
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (16)

C

Chenlong Wei

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences

X

Xinzhu Shan

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences

Y

Yuxuan Huang

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences

B

Bin Ma

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences

Z

Zhiqiang Zhao

Department of Materials Science and Engineering

Y

Yian Fang

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences

C

Chengrui Bai

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences

Z

Zihan Zhang

P

Peng Zhao

H

Huijuan Zhang

Department of Oncology The Affiliated Yantai Yuhuangding Hospital of Qingdao University Medical College Yantai China

Y

Yu Hou

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences

T

Tianjiao Ji

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology

Z

Zhongtang Li

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences

S

Song Song

State Key Laboratory of Chemical Engineering and Low-Carbon Technology, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Haihe Laboratory of Sustainable Chemical Transformations, Tianjin Key Laboratory of Applied Catalysis Science and Engineering, School of Chemical Engineering & Technology

F

Fei Xie

State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China

L

Lei Miao

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences