Fabrication, spectroscopic inspection, biological evaluation of some transition metal complexes with bis- azomethine ligand and γ-ray irradiation dose effect

Abstract

Abstract A new bis- azomethine ligand N′,N′′′-(2,2′-(((1E,1′E)-cyclohexa-2,5-diene-1,4-diylbis(methanylylidene))bis(azanylylidene))bis(benzoyl))di(picolinohydrazide) and its Cd+2 (1), Hg+2 (2) and Co+2 (3) complexes have been fabricated. Via FT-IR, UV/Vis., 1H-NMR spectroscopy and XRD, in addition to magnetic moment, elemental, molar conductance and thermal analysis, the structure of synthesized compounds was explored. The parent complexes (1,2) have been irradiated by 60Co radioactive source γ-rays at room temperature with dose values of 150 and 200 kGy to get irradiated samples (1R and 1R*) and (2R and 2R*), respectively. The structural of the irradiated samples were studied by the same techniques as for the parent complexes. The cytotoxicity of the ligand and its Cd+2 and Hg+2 complexes against breast (MCF-7) and hepatocellular cancerous cells (HepG-2) was evaluated. The chelates are significantly more potent compared to the ligand. Moreover, these compounds have been screened for their antimicrobial potency. The finding showed that the parent metal complexes demonstrated promising antimicrobial activity against gram −ve (Escherichia coli) and gram + ve (Staphylococcus aureus) bacterial species and two fungal species (Candida albicans and Aspergillus nigar) as well. The complexes exhibited greater antimicrobial potency than Ampicillin and Nystatin.